General and Facile Surface Functionalization of Hydrophobic Nanocrystals with Poly(amino acid) for Cell Luminescence Imaging

被引：55

作者：

Huang, Sheng ^{[1
]}

Bai, Min ^{[1
]}

Wang, Leyu ^{[1
]}

机构：

[1] Beijing Univ Chem Technol, Sch Sci, State Key Lab Chem Resource Engn, Beijing 100029, Peoples R China

来源：

SCIENTIFIC REPORTS | 2013年 / 3卷

基金：

中国国家自然科学基金;

关键词：

QUANTUM DOTS; GOLD NANOPARTICLES; NANORODS; ENCAPSULATION; NANOSPHERES; STRATEGY; LIGANDS;

D O I：

10.1038/srep02023

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Hydrophobic nanocrystals with various shape, size, and chemical composition were successfully functionalized by poly(amino acid) with one particle per micelle without aggregation or precipitation via a facile, general, and low-cost strategy. Via simply tuning the pH value, multifunctional nanocomposites consisting of different nanocrystals were also fabricated. Due to the poly(amino acid) coating, these nanocrystals are highly water-stable, biocompatible, and bioconjugatable with chemical and biological moieties. Meanwhile, their shape, size, optical/magnetic properties are well retained, which is highly desirable for bioapplications. This developed strategy presents a novel opportunity to apply hydrophobic nanocrystals to various biomedical fields.

引用

页数：5

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