Palladium-catalyzed ortho-selective C-H bond chlorination of aromatic ketones

被引：9

作者：

Shan, Gang ^{[2
,3
]}

Huang, Gui-Yi ^{[1
,2
,3
]}

Rao, Yu ^{[2
,3
]}

Zhang, Hui ^{[1
]}

机构：

[1] Shenyang Pharmaceut Univ, Sch Pharmaceut Engn, Shenyang 110016, Peoples R China

[2] Tsinghua Univ, Sch Med, Dept Pharmacol & Pharmaceut Sci, MOE Key Lab Prot Sci, Beijing 100084, Peoples R China

[3] Tsinghua Univ, Sch Life Sci, Beijing 100084, Peoples R China

来源：

CHINESE CHEMICAL LETTERS | 2015年 / 26卷 / 10期

关键词：

Palladium catalysis; C-H chlorination; Aromatic ketones; ONE-POT SYNTHESIS; BIOLOGICAL-ACTIVITY; WEAK COORDINATION; HALOGENATION; ACYLATION; ARENES; REACTIVITY; EFFICIENT;

D O I：

10.1016/j.cclet.2015.07.011

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A palladium-catalyzed ortho-selective C-H bond chlorination reaction for the preparation of 2-chloro aromatic ketones was described. Both electron-withdrawing and electron-donating groups on the aromatic rings are well tolerated under the optimized conditions. The 2-chloro aromatic ketones obtained by our method could be applied to synthesize the derivatives of 1H-indazole or benzo[d]isoxazole. (C) 2015 Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences. Published by Elsevier B.V. All rights reserved.

引用

页码：1236 / 1240

页数：5

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