Shhh! Silencing by microRNA-155

被引：54

作者：

Teng, Grace ^{[1
]}

Papavasiliou, F. Nina ^{[1
]}

机构：

[1] Rockefeller Univ, Lab Lymphocyte Biol, New York, NY 10065 USA

来源：

PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES | 2009年 / 364卷 / 1517期

基金：

美国国家卫生研究院;

关键词：

RNAi; miRNA; miR-155; innate immunity; adaptive immunity; INDUCED CYTIDINE DEAMINASE; VIRUS-INDUCED LYMPHOMAS; DOUBLE-STRANDED-RNA; B-CELL LYMPHOMAS; GENE-EXPRESSION; MESSENGER-RNA; C-ELEGANS; BURKITT-LYMPHOMA; NONCODING RNA; MIR-155;

D O I：

10.1098/rstb.2008.0209

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Small RNAsmediate a diverse pot-pourri of post-transcriptional silencing mechanisms, ranging from 'classical' RNA interference (RNAi), to gene repression by microRNAs ( miRNAs), to maintenance of genomic stability by repeat-associated small RNAs. Here, we review recent findings on the function of miR-155, particularly its roles in mammalian innate and adaptive immunity, viral infection and oncogenesis.

引用

页码：631 / 637

页数：7

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