Development of drug intermediates by using direct organocatalytic multi-component reactions

被引：76
作者：
Ramachary, DB [1 ]
Kishor, M [1 ]
Reddy, GB [1 ]
机构：
[1] Univ Hyderabad, Sch Chem, Hyderabad 500046, Andhra Pradesh, India
来源：
ORGANIC & BIOMOLECULAR CHEMISTRY | 2006年 / 4卷 / 09期
关键词：
D O I：
10.1039/b602696f
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Novel, economic and environmentally friendly one-pot three-component Knoevenagel/hydrogenation (K/H) and four-component Knoevenagel/hydrogenation/alkylation (K/H/A) reactions of ketones, CH-acids, dihydropyridines and alkyl halides using proline and proline/metal carbonate catalysis, respectively, have been developed. Many of the products of these K/H and K/H/A reactions have direct applications in pharmaceutical chemistry.
引用
收藏
页码：1641 / 1646
页数：6
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