Palladium-Catalyzed Carbonylation-Decarboxylation of Diethyl(2-iodoaryl)malonates with Imidoyl Chlorides: An Efficient Route to Substituted Isoquinolin-1(2H)-ones

被引：59

作者：

Zheng, Zhaoyan ^{[1
]}

Alper, Howard ^{[1
]}

机构：

[1] Univ Ottawa, Dept Chem, Ctr Catalysis Res & Innovat, Ottawa, ON K1N 6N5, Canada

来源：

ORGANIC LETTERS | 2008年 / 10卷 / 21期

基金：

加拿大自然科学与工程研究理事会;

关键词：

D O I：

10.1021/ol801991m

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A wide variety of substituted isoquinolin-1(2H)-ones were synthesized in reasonable to good yields by the palladium-catalyzed cyclization of diethyl(2-iodoaryl)malonates with imidoyl chlorides and carbon monoxide in tetrahydrofuran. A palladium-catalyzed carbonylation-decarboxylation process may be involved in the one-step synthesis of the isoquinolin-1(2H)-ones.

引用

页码：4903 / 4906

页数：4

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