Pd-Catalyzed Tandem Cyclization of Ethyl Glyoxalate and Amines: Rapid Assembly of Highly Substituted Cyclic Dehydro-α-Amino Acid Derivatives

被引：26

作者：

Luo, Yueting ^{[1
]}

Lu, Xiaoxia ^{[2
]}

Ye, Yong ^{[1
]}

Guo, Ya ^{[1
]}

Jiang, Huanfeng ^{[1
]}

Zeng, Wei ^{[1
]}

机构：

[1] S China Univ Technol, Sch Chem & Chem Engn, Guangzhou 510641, Guangdong, Peoples R China

[2] Acad Sci, Chengdu Inst Biol, Chengdu 610041, Peoples R China

来源：

ORGANIC LETTERS | 2012年 / 14卷 / 22期

关键词：

C-H BOND; EFFICIENT SYNTHESIS; ANNULATION; CARBOXYLATION; ALDEHYDES; ARYL;

D O I：

10.1021/ol302483f

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A novel cascade cyclization of ethyl glyoxalate and amines proceeds in the presence of Pd(TFA)(2) (5 mol %) to give the cyclic dehydro-a-amino acid derivatives. This method provides a fast and simple access to highly substituted dihydro-pyrrol-2-ones in good yields.

引用

页码：5640 / 5643

页数：4

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