Telocytes and lung disease

被引：22

作者：

Song, Dongli ^{[1
]}

Cretoiu, Dragos ^{[2
,3
]}

Cretoiu, Sanda M. ^{[2
,3
]}

Wang, Xiangdong ^{[1
]}

机构：

[1] Fudan Univ, Zhongshan Hosp, Ctr Clin Bioinformat, Shanghai Inst Clin Bioinformat, Shanghai, Peoples R China

[2] Carol Davila Univ Med & Pharm, Dept Morphol Sci, Div Cellular & Mol Biol & Histol, Bucharest, Romania

[3] Victor Babes Natl Inst Pathol, Bucharest, Romania

来源：

HISTOLOGY AND HISTOPATHOLOGY | 2016年 / 31卷 / 12期

关键词：

Telocytes; Interstitial lung disease; Pulmonary fibrosis; Chronic obstructive pulmonary disease; Lung cancer; IDIOPATHIC PULMONARY-FIBROSIS; MESENCHYMAL STEM-CELLS; AIRWAY EPITHELIAL-CELLS; CARDIAC TELOCYTES; EXTRACELLULAR VESICLES; INTERSTITIAL-CELLS; CAJAL-LIKE; II CELLS; ELECTRON-MICROSCOPY; PROTEOMIC ANALYSIS;

D O I：

10.14670/HH-11-807

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Telocytes (TCs) represent a new distinct type of interstitial cells found in many organs, including lungs. TCs are mainly defined by a small cellular body from which arise very long (hundreds of micrometers) extensions named telopodes. During the last years, TCs were characterized in respect with their microRNA profiles, gene features and proteome signatures. Also, the ultrastructural 3D configuration was further elucidated by the aid of the FIB-SEM technology. TCs are able to communicate by homo- and heterocellular contacts with neighboring cells and are also able to transfer genetic information and signaling molecules to influence other cells by means of extracellular vesicle release. However, the exact function of lung TCs remains unclear. Here, we review the potential significance of TCs in the pathogenesis of pulmonary diseases. We will also discuss some future possibilities for targeting TCs as a potential therapeutic strategy.

引用

页码：1303 / 1314

页数：12

共 118 条

[1] Rejuvenating cellular respiration for optimizing respiratory function: targeting mitochondria [J].