Design, synthesis, and anti-tumor activities of novel triphenylethylene-coumarin hybrids, and their interactions with Ct-DNA

被引：66

作者：

Chen, Hua ^{[1
]}

Li, Shuai ^{[1
]}

Yao, Yuchao ^{[1
]}

Zhou, Likai ^{[1
]}

Zhao, Jianpeng ^{[1
]}

Gu, Yunjing ^{[1
]}

Wang, Kerang ^{[1
]}

Li, Xiaoliu ^{[1
]}

机构：

[1] Hebei Univ, Coll Chem & Environm Sci, Key Lab Chem Biol Hebei Prov, Baoding 071002, Peoples R China

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2013年 / 23卷 / 17期

基金：

中国国家自然科学基金;

关键词：

Coumarin; Triphenylethylene; Anti-tumor activities; DNA binding property; BINDING; DERIVATIVES; INHIBITORS; DOCKING;

D O I：

10.1016/j.bmcl.2013.07.009

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Novel triphenylethylene-coumarin hybrid derivatives containing different amounts of amino side chains Were designed and synthesized in good yields under microwave radiation. The derivatives 5b-d which possessed two amino side chains (except morpholinyl) showed a broad-spectrum and good anti-proliferative activity against five tumor cells and low cytotoxicity in osteoblast. UV-vis, fluorescence, and circular dichroism (CD) spectroscopies and thermal denaturation exhibited that compounds 10c, 5c, and 13c bearing amino side chain (except morpholinyl) on 4-phenyl had significant interactions with Ct-DNA by the intercalative mode of binding. Structure-activity relationships (SARs) analysis suggested that the amino alkyl chain would play an important role both in the compounds against tumor cells proliferation and their interactions with DNA. (C) 2013 Elsevier Ltd. All rights reserved.

引用

收藏

页码：4785 / 4789

页数：5

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