A novel route to functionalized PFP esters via rapid intermolecular radical addition to PFP acrylate mediated by ethylpiperidinium hypophosphite (EPHP)

被引：13
作者：
Caddick, S
Hamza, D
Judd, DB
Reich, MT
Wadman, SN
Wilden, JD
机构：
[1] UCL, Dept Chem, London WC1H 0AJ, England
[2] GlaxoSmithKline, Harlow CM19 5AW, Essex, England
[3] Univ Sussex, Ctr Mol Design & Drug Dev, Brighton BN1 9QJ, E Sussex, England
[4] GlaxoSmithKline, High Throughput Chem, Stevenage SG1 2NY, Herts, England
来源：
TETRAHEDRON LETTERS | 2004年 / 45卷 / 11期
基金：
英国生物技术与生命科学研究理事会; 英国工程与自然科学研究理事会;
关键词：
EPHP; radical; addition; amides; PFP esters;
D O I：
10.1016/j.tetlet.2004.01.082
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Pentafluorophenyl (PFP) acrylate, a stable compact bifunctional scaffold undergoes rapid N-ethylpiperidinium hypophosphite (EPHP) mediated conjugate radical addition to yield a variety of active esters susceptible to further functionalization by aminolysis. (C) 2004 Published by Elsevier Ltd.
引用
收藏
页码：2363 / 2366
页数：4
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