Upconversion-mediated ZnFe2O4 nanoplatform for NIR-enhanced chemodynamic and photodynamic therapy

被引:169
作者
Dong, Shuming [1 ]
Xu, Jiating [1 ]
Jia, Tao [1 ]
Xu, Mengshu [1 ]
Zhong, Chongna [1 ]
Yang, Guixin [1 ]
Li, Jiarong [1 ]
Yang, Dan [1 ]
He, Fei [1 ]
Gai, Shili [1 ]
Yang, Piaoping [1 ]
Lin, Jun [2 ]
机构
[1] Harbin Engn Univ, Coll Mat Sci & Chem Engn, Key Lab Superlight Mat & Surface Technol, Minist Educ, Harbin 150001, Heilongjiang, Peoples R China
[2] Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Rare Earth Resource Utilizat, Changchun 130021, Jilin, Peoples R China
基金
中国国家自然科学基金; 中国博士后科学基金;
关键词
PHOTO-FENTON REACTION; SILICA NANOPARTICLES; SYNERGISTIC THERAPY; ENERGY MIGRATION; NANOCRYSTALS; GENERATION; DYE; NANOASSEMBLIES; MECHANISMS; PLATFORM;
D O I
10.1039/c9sc00387h
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
ZnFe2O4, a semiconductor catalyst with high photocatalytic activity, is ultrasensitive to ultraviolet (UV) light and tumor H2O2 for producing reactive oxygen species (ROS). Thereby, ZnFe2O4 can be used for photodynamic therapy (PDT) from direct electron transfer and the newly defined chemodynamic therapy (CDT) from the Fenton reaction. However, UV light has confined applicability because of its high phototoxicity, low penetration, and speedy attenuation in the biotissue. Herein, an upconversion-mediated nanoplatform with a mesoporous ZnFe2O4 shell was developed for near-infrared (NIR) light enhanced CDT and PDT. The nanoplatform (denoted as Y-UCSZ) was comprised of upconversion nanoparticles (UCNPs), silica shell, and mesoporous ZnFe2O4 shell and was synthesized through a facile hydrothermal method. The UCNPs can efficiently transfer penetrable NIR photons to UV light, which can activate ZnFe2O4 for producing singlet oxygen thus promoting the Fenton reaction for ROS generation. Besides, Y-UCSZ possesses enormous internal space, which is highly beneficial for housing DOX (doxorubicin, a chemotherapeutic agent) to realize chemotherapy. Moreover, the T-2-weighted magnetic resonance imaging (MRI) effect from Fe3+ and Gd3+ ions in combination with the inherent upconversion luminescence (UCL) imaging and computed tomography (CT) from the UCNPs makes an all-in-one diagnosis and treatment system. Importantly, in vitro and in vivo assays authenticated excellent biocompatibility of the PEGylated Y-UCSZ (PEG/Y-UCSZ) and high anticancer effectiveness of the DOX loaded PEG/Y-UCSZ (PEG/Y-UCSZ&DOX), indicating its potential application in the cancer treatment field.
引用
收藏
页码:4259 / 4271
页数:13
相关论文
共 66 条
[51]   Antigen-Loaded Upconversion Nanoparticles for Dendritic Cell Stimulation, Tracking, and Vaccination in Dendritic Cell-Based Immunotherapy [J].
Xiang, Jian ;
Xu, Ligeng ;
Gong, Hua ;
Zhu, Wenwen ;
Wang, Chao ;
Xu, Jun ;
Feng, Liangzhu ;
Cheng, Liang ;
Peng, Rui ;
Liu, Zhuang .
ACS NANO, 2015, 9 (06) :6401-6411
[52]   Tumor Microenvironment-Responsive Mesoporous MnO2-Coated Upconversion Nanoplatform for Self-Enhanced Tumor Theranostics [J].
Xu, Jiating ;
Han, Wei ;
Yang, Piaoping ;
Jia, Tao ;
Dong, Shuming ;
Bi, Huiting ;
Gulzar, Arif ;
Yang, Dan ;
Gai, Shili ;
He, Fei ;
Lin, Jun ;
Li, Chunxia .
ADVANCED FUNCTIONAL MATERIALS, 2018, 28 (36)
[53]   Bioresponsive and near infrared photon co-enhanced cancer theranostic based on upconversion nanocapsules [J].
Xu, Jiating ;
Han, Wei ;
Cheng, Ziyong ;
Yang, Piaoping ;
Bi, Huiting ;
Yang, Dan ;
Niu, Na ;
He, Fei ;
Gai, Shili ;
Lin, Jun .
CHEMICAL SCIENCE, 2018, 9 (12) :3233-3247
[54]   Yolk-Structured Upconversion Nanoparticles with Biodegradable Silica Shell for FRET Sensing of Drug Release and Imaging-Guided Chemotherapy [J].
Xu, Jiating ;
He, Fei ;
Cheng, Ziyong ;
Lv, Ruichan ;
Dai, Yunlu ;
Gulzar, Arif ;
Liu, Bin ;
Bi, Huiting ;
Yang, Dan ;
Gai, Shili ;
Yang, Piaoping ;
Lin, Jun .
CHEMISTRY OF MATERIALS, 2017, 29 (17) :7615-7628
[55]   Recent advances in multifunctional magnetic nanoparticles and applications to biomedical diagnosis and treatment [J].
Yan, Kai ;
Li, Penghui ;
Zhu, Haie ;
Zhou, Yingjie ;
Ding, Jingde ;
Shen, Jie ;
Li, Zheng ;
Xu, Zushun ;
Chu, Paul K. .
RSC ADVANCES, 2013, 3 (27) :10598-10618
[56]   Hollow MnO2 as a tumor-microenvironment-responsive biodegradable nano-platform for combination therapy favoring antitumor immune responses [J].
Yang, Guangbao ;
Xu, Ligeng ;
Chao, Yu ;
Xu, Jun ;
Sun, Xiaoqi ;
Wu, Yifan ;
Peng, Rui ;
Liu, Zhuang .
NATURE COMMUNICATIONS, 2017, 8
[57]   Upconversion Luminescent Chemodosimeter Based on NIR Organic Dye for Monitoring Methylmercury In Vivo [J].
Yang, Huiran ;
Han, Chunmiao ;
Zhu, Xingjun ;
Liu, Yi ;
Zhang, Kenneth Yin ;
Liu, Shujuan ;
Zhao, Qiang ;
Li, Fuyou ;
Huang, Wei .
ADVANCED FUNCTIONAL MATERIALS, 2016, 26 (12) :1945-1953
[58]   Selenium Doped Graphene Quantum Dots as an Ultrasensitive Redox Fluorescent Switch [J].
Yang, Siwei ;
Sun, Jing ;
He, Peng ;
Deng, Xinxia ;
Wang, Zhongyang ;
Hu, Chenyao ;
Ding, Guqiao ;
Xie, Xiaoming .
CHEMISTRY OF MATERIALS, 2015, 27 (06) :2004-2011
[59]   Synergistically enhanced photocatalytic activity of graphitic carbon nitride and WO3 nanohybrids mediated by photo-Fenton reaction and H2O2 [J].
Yoon, Minji ;
Oh, Youngtak ;
Hong, Sugyeong ;
Lee, June Sang ;
Boppella, Ramireddy ;
Kim, Sun Hee ;
Mota, Filipe Marques ;
Kim, Sang Ouk ;
Kim, Dong Ha .
APPLIED CATALYSIS B-ENVIRONMENTAL, 2017, 206 :263-270
[60]   Enhanced Photocatalytic and Fenton-like Performance of CuOx-Decorated ZnFe2O4 [J].
Zhao, Wei ;
Liang, Chuan ;
Wang, Beibei ;
Xing, Shengtao .
ACS APPLIED MATERIALS & INTERFACES, 2017, 9 (48) :41927-41936