Role of FGFs/FGFRs in skeletal development and bone regeneration

被引：99
作者：
Du, Xiaolan [1 ]
Xie, Yangli [1 ]
Xian, Cory J. [2 ]
Chen, Lin [1 ]
机构：
[1] Third Mil Med Univ, State Key Lab Trauma Burns & Combined Injury, Ctr Bone Metab & Repair, Inst Surg Res,Daping Hosp, Chongqing 400042, Peoples R China
[2] Univ S Australia, Sch Pharm & Med Sci, Sansom Inst Hlth Res, Adelaide, SA 5001, Australia
来源：
JOURNAL OF CELLULAR PHYSIOLOGY | 2012年 / 227卷 / 12期
基金：
中国国家自然科学基金;
关键词：
FIBROBLAST-GROWTH-FACTOR; FAMILIAL TUMORAL CALCINOSIS; TEMPORAL GENE-EXPRESSION; FACTOR RECEPTOR-3 FGFR3; PROTEIN-KINASE-C; FRACTURE REPAIR; NATRIURETIC PEPTIDE; ACANTHOSIS NIGRICANS; TRANSGENIC MICE; APERT-SYNDROME;
D O I：
10.1002/jcp.24083
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Fibroblast growth factor (FGF)/FGF (FGFR) signaling is an important pathway involved in skeletal development. Missense mutations in FGFs and FGFRs were found clinically to cause multiple congenital skeleton diseases including chondrodysplasia, craniosynostosis, syndromes with dysregulated phosphate metabolism. FGFs/FGFRs also have crucial roles in bone fracture repair and bone regeneration. Understanding the molecular mechanisms for the role of FGFs/FGFRs in the regulation of skeletal development, genetic skeletal diseases, and fracture healing will ultimately lead to better treatment of skeleton diseases caused by mutations of FGFs/FGFRs and fracture. This review summarizes the major findings on the role of FGF signaling in skeletal development, genetic skeletal diseases and bone healing, and discusses issues that remain to be resolved in applying FGF signaling-related measures to promote bone healing. This review has also provided a perspective view on future work for exploring the roles and action mechanisms of FGF signaling in skeletal development, genetic skeletal diseases, and fracture healing. J. Cell. Physiol. 227: 37313743, 2012. (c) 2012 Wiley Periodicals, Inc.
引用
收藏
页码：3731 / 3743
页数：13
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