The antioxidative effect of ganhuangenin against lipid peroxidation

被引：1
|
作者：
Lim, BO
Yu, BP [1 ]
Kim, SC
Park, DK
机构：
[1] Univ Texas, Hlth Sci Ctr, Dept Physiol, San Antonio, TX 78284 USA
[2] Korea Ginseng & Tobacco Res Inst, Taejon 305345, South Korea
[3] Konkuk Univ, Dept Biochem, Choongju 380701, South Korea
[4] Konkuk Univ, Anim Res Ctr, Choongju 380701, South Korea
来源：
PHYTOTHERAPY RESEARCH | 1999年 / 13卷 / 06期
关键词：
Scutellaria baicalensis Georgi; ganhuangenin; lipid peroxidation; hydroperoxide; antioxidative activity; oxidative stress;
D O I：
10.1002/(SICI)1099-1573(199909)13:6<479::AID-PTR484>3.0.CO;2-M
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
The antioxidative effect of ganhuangenin (GHG), isolated from Scutellaria baicalensis Georgi, was examined by measuring its ability to suppress the formation of phospatidylcholine hydroperoxide (PCOOH). The results show that a pretreatment with GHG effectively suppressed PCOOH formation, which was initiated by the peroxyl-generating oxidant, AAPH (2,2'-azobis-2-aminopropane hydrochloride). The protective action of GHG against the formation of the PCOOH was observed in liver, lung, and kidney. When compared with other known antioxidants, we found the antioxidative potency of GHG to be greater than that of alpha-tocopherol. Our data strongly indicate that GHG is a powerful antioxidant against lipid peroxidation and is, therefore, responsible for this prophylactic effect.
引用
收藏
页码：479 / 483
页数：5
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