Antihyperglycemic treatment guidelines for diabetes mellitus type 2 (Update 2019)

被引：17

作者：

Clodi, Martin ^{[1
,2
]}

Abrahamian, Heidemarie ^{[3
]}

Brath, Helmut ^{[4
]}

Brix, Johanna ^{[5
]}

Drexel, Heinz ^{[6
,7
,8
,9
,10
]}

Fasching, Peter ^{[11
]}

Foeger, Bernhard ^{[12
,13
]}

Francesconi, Claudia ^{[14
]}

Froehlich-Reiterer, Elke ^{[15
]}

Harreiter, Juergen ^{[16
]}

Hofer, Sabine E. ^{[17
]}

Hoppichler, Friedrich ^{[18
]}

Huber, Joakim ^{[19
]}

Kaser, Susanne ^{[20
,21
]}

Kautzky-Willer, Alexandra ^{[22
]}

Lechleitner, Monika ^{[23
]}

Ludvik, Bernhard ^{[5
]}

Luger, Anton ^{[16
]}

Mader, Julia K. ^{[24
]}

Paulweber, Bernhard ^{[25
]}

Pieber, Thomas ^{[26
]}

Prager, Rudolf ^{[27
]}

Rami-Merhar, Birgit ^{[28
]}

Resl, Michael ^{[1
,2
]}

Riedl, Michaela ^{[16
]}

Roden, Michael ^{[29
,30
,31
]}

Saely, Christoph H. ^{[32
]}

Schelkshorn, Christian ^{[33
]}

Schernthaner, Guntram ^{[5
]}

Sourij, Harald ^{[24
]}

Stechemesser, Lars ^{[25
]}

Stingl, Harald ^{[34
]}

Toplak, Hermann ^{[24
]}

Wascher, Thomas C. ^{[35
]}

Weitgasser, Raimund ^{[36
,37
]}

Winhofer-Stoeckl, Yvonne ^{[16
]}

Zlamal-Fortunat, Sandra ^{[38
]}

机构：

[1] Johannes Kepler Univ Linz, ICMR, A-4040 Linz, Austria

[2] Konventhospital Barmherzigen Bruder Linz, Abt Innere Med Diabetol Gastroenterol & Hepatol R, A-4021 Linz, Austria

[3] Otto Wagner Spital, Internist Zentrum Baumgartner Hohe, Vienna, Austria

[4] Gesundheitszentrum Wien Sud, Diabet Ambulanz, Vienna, Austria

[5] Krankenanstalt Rudolfstiftung Wien, Med Abt Diabetol Endokrinol & Nephrol 1, Vienna, Austria

[6] VIVIT, Feldkirch, Austria

[7] Chair ESC Working Grp, Cardiovasc Pharmacotherapy, Sophia Antipolis, France

[8] Univ Spital Bern, Abt Angiol, Bern, Switzerland

[9] Drexel Univ, Coll Med, Philadelphia, PA 19104 USA

[10] Private Univ Furstentum Liechtenstein, Liechtenstein, Liechtenstein

[11] Wilhelminenspital Stadt Wien, Med Abt Endokrinol Rheumatol & Akutgeriatrie 5, Vienna, Austria

[12] Landeskrankenhaus Bregenz, Interne Abt, Bregenz, Austria

[13] AKS Gesundheit, Bregenz, Austria

[14] Sonderkrankenanstalt Rehabil Zentrum Allan, Alland, Austria

[15] Med Univ Graz, Univ Klin Kinder & Jugendheilkunde, Graz, Austria

[16] Med Univ Wien, Univ Klin Innere Med, Klin Abt Endokrinol & Stoffwechsel, Vienna, Austria

[17] Med Univ Innsbruck, Dept Padiat 1, Innsbruck, Austria

[18] Krankenhaus Barmherzigen Bruder Salzburg, Abt Innere Med, Salzburg, Austria

[19] Franziskus Spital, Interne Abt Akutgeriatrie & Palliat Med, Standort Landstr, Vienna, Austria

[20] Med Univ Innsbruck, Dept Innere Med 1, Innsbruck, Austria

[21] Med Univ Innsbruck, Christian Doppler Labor Insulinresistenz, Innsbruck, Austria

[22] Med Univ Wien, Univ Klin Innere Med 3, Klin Abt Endokrinol & Stoffwechsel, Gender Med Unit, Vienna, Austria

[23] Landeskrankenhaus Hochzirl Natters, Interne Abt, Hochzirl, Austria

[24] Med Univ Graz, Univ Klin Innere Med, Klin Abt Endokrinol & Diabetol, Graz, Austria

[25] Paracelsus Med Privatuniv, Univ Klin Innere Med 1, Gastroenterol Hepatol Nephrol Stoffwechsel & Diab, Salzburg, Austria

[26] Med Univ Graz, Univ Klin Innere Med, Graz, Austria

[27] Krankenhaus Hietzing Wien, Med Abt Stoffwechselerkrankungen & Nephrol, Vienna, Austria

[28] Med Univ Wien, Univ Klin Kinder & Jugendheilkunde, Vienna, Austria

[29] Heinrich Heine Univ, Med Fak, Klin Endokrinol & Diabetol, Dusseldorf, Germany

[30] DZD eV, Deutsch Zentrum Diabetesforsch, Munich, Germany

[31] Leibniz Zentrum Diabetesforsch, DDZ, Inst Klin Diabetol, Dusseldorf, Germany

[32] Akad Lehrkrankenhaus Feldkirch, Abt Innere Med I, Feldkirch, Austria

[33] Landesklinikum Stockerau, Med Abt 1, Stockerau, Austria

[34] Landesklinikum Melk, Abt Innere Med, Melk, Austria

[35] Hanusch Hosp, Med Abt 1, Vienna, Austria

[36] Privatklin Wehrle Diakonissen, Abt Innere Med, Salzburg, Austria

[37] Paracelsus Med Privatuniv, LKH Salzburg Univ Klinikum, Univ Klin Innere Med 1, Salzburg, Austria

[38] Klinikum Klagenfurt Worthersee, Abt Innere Med & Gastroenterol, Klagenfurt, Austria

来源：

WIENER KLINISCHE WOCHENSCHRIFT | 2019年 / 131卷 / Suppl 1期

关键词：

Diabetes mellitus Type2; Therapy; Glucose lowering; PIOGLITAZONE CLINICAL-TRIAL; CARDIOVASCULAR OUTCOMES; MACROVASCULAR EVENTS; GLUCOSE CONTROL; DISEASE; EMPAGLIFLOZIN;

D O I：

10.1007/s00508-019-1471-z

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Hyperglycemia significantly contributes to complications in patients with diabetes mellitus. While lifestyle interventions remain cornerstones of disease prevention and treatment, most patients with type2 diabetes will eventually require pharmacotherapy for glycemic control. The definition of individual targets regarding optimal therapeutic efficacy and safety as well as cardiovascular effects is of great importance. In this guideline we present the most current evidence-based best clinical practice data for healthcare professionals.

引用

页码：27 / 38

页数：12

共 27 条

[1]

Davies MJ, 2018, DIABETES CARE, V41, P2669, DOI [10.2337/dci18-0033, 10.1007/s00125-018-4729-5]

[2] Secondary prevention of macrovascular events in patients with type 2 diabetes in the PROactive Study (PROspective pioglitAzone Clinical Trial In macroVascular Events):: a randomised controlled trial [J].

Dormandy, JA ;

Charbonnel, B ;

Eckland, DJA ;

Erdmann, E ;

Massi-Benedetti, M ;

Kmoules, IK ;

Skene, AM ;

Tan, MH ;

Lefébvre, PJ ;

Murray, GD ;

Standl, E ;

Wilcox, RG ;

Wlhelmsen, L ;

Betteridge, J ;

Birkeland, K ;

Golay, A ;

Heine, RJ ;

Korányi, L ;

Laakso, M ;

Mokán, M ;

Norkus, A ;

Pirags, V ;

Podar, T ;

Scheen, A ;

Scherbaum, W ;

Schernthaner, G ;

Schmitz, O ;

Skrha, J ;

Smith, U ;

Taton, J .

LANCET, 2005, 366 (9493) :1279-1289

[3] Glucose Control and Vascular Complications in Veterans with Type 2 Diabetes [J].

Duckworth, William ;

Abraira, Carlos ;

Moritz, Thomas ;

Reda, Domenic ;

Emanuele, Nicholas ;

Reaven, Peter D. ;

Zieve, Franklin J. ;

Marks, Jennifer ;

Davis, Stephen N. ;

Hayward, Rodney ;

Warren, Stuart R. ;

Goldman, Steven ;

McCarren, Madeline ;

Vitek, Mary Ellen ;

Henderson, William G. ;

Huang, Grant D. .

NEW ENGLAND JOURNAL OF MEDICINE, 2009, 360 (02) :129-U62

[4] The effect of pioglitazone on recurrent myocardial infarction in 2,445 patients with type 2 diabetes and previous myocardial infarction - Results from the PROactive (PROactive 05) study [J].

Erdmann, Erland ;

Dormandy, John A. ;

Charbonnel, Bernard ;

Massi-Benedetti, Massimo ;

Moules, Ian K. ;

Skene, Allan M. .

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2007, 49 (17) :1772-1780

[5] Impact of glucose-lowering drugs on cardiovascular disease in type 2 diabetes [J].

Ferrannini, Ele ;

DeFronzo, Ralph A. .

EUROPEAN HEART JOURNAL, 2015, 36 (34) :2288-U19

[6]

Gerstein HC, 2008, NEW ENGL J MED, V358, P2545, DOI 10.1056/NEJMoa0802743

[7] Basal Insulin and Cardiovascular and Other Outcomes in Dysglycemia [J].

Gerstein, Hertzel C. ;

Bosch, Jackie ;

Dagenais, Gilles R. ;

Diaz, Rafael ;

Jung, Hyejung ;

Maggioni, Aldo P. ;

Pogue, Janice ;

Probstfield, Jeffrey ;

Ramachandran, Ambady ;

Riddle, Matthew C. ;

Ryden, Lars E. ;

Yusuf, Salim .

NEW ENGLAND JOURNAL OF MEDICINE, 2012, 367 (04) :319-328

[8] Effect of Sitagliptin on Cardiovascular Outcomes in Type 2 Diabetes [J].

Green, Jennifer B. ;

Bethel, M. Angelyn ;

Armstrong, Paul W. ;

Buse, John B. ;

Engel, Samuel S. ;

Garg, Jyotsna ;

Josse, Robert ;

Kaufman, Keith D. ;

Koglin, Joerg ;

Korn, Scott ;

Lachin, John M. ;

McGuire, Darren K. ;

Pencina, Michael J. ;

Standl, Eberhard ;

Stein, Peter P. ;

Suryawanshi, Shailaja ;

Van de Werf, Frans ;

Peterson, Eric D. ;

Holman, Rury R. .

NEW ENGLAND JOURNAL OF MEDICINE, 2015, 373 (03) :232-242

[9] 10-year follow-up of intensive glucose control in type 2 diabetes [J].

Holman, Rury R. ;

Paul, Sanjoy K. ;

Bethel, M. Angelyn ;

Matthews, David R. ;

Neil, H. Andrew W. .

NEW ENGLAND JOURNAL OF MEDICINE, 2008, 359 (15) :1577-1589

[10] Effects of acarbose on cardiovascular and diabetes outcomes in patients with coronary heart disease and impaired glucose tolerance (ACE): a randomised, double-blind, placebo-controlled trial [J].

Holman, Rury R. ;

Coleman, Roth L. ;

Chan, Juliana C. N. ;

Chiasson, Jean-Louis ;

Feng, Huimei ;

Ge, Junbo ;

Gerstein, Hertzel C. ;

Gray, Richard ;

Huo, Yong ;

Lang, Zhihui ;

McMurray, John ;

Ryden, Lars ;

Schroeder, Stefan ;

Sun, Yihong ;

Theodorakis, Michael J. ;

Tendera, Michal ;

Tucker, Lynne ;

Tuomilehto, Jaakko ;

Wei, Yidong ;

Yang, Wenying ;

Wang, Duolao ;

Hu, Dayi ;

Pan, Changyu .

LANCET DIABETES & ENDOCRINOLOGY, 2017, 5 (11) :877-886

← 1 2 3 →