Improving flow properties of ibuprofen by fluidized bed particle thin-coating

被引：26

作者：

Ehlers, Henrik ^{[1
]}

Raikkonen, Heikki ^{[1
]}

Antikainen, Osmo ^{[1
]}

Heinamaki, Jyrki ^{[1
]}

Yliruusi, Jouko ^{[1
]}

机构：

[1] Univ Helsinki, Fac Pharm, Div Pharmaceut Technol, FI-00014 Helsinki, Finland

来源：

INTERNATIONAL JOURNAL OF PHARMACEUTICS | 2009年 / 368卷 / 1-2期

关键词：

Particle thin-coating; Fluidized bed coating; Powder flow; Ibuprofen; HPMC; Surface properties; PHARMACEUTICAL POWDERS; AGGLOMERATION TENDENCY; POLYMERIC SUSPENSION; SUPPRESSION; PARAMETERS; GROWTH; GRANULATION; EXCIPIENTS; STRENGTH; MOISTURE;

D O I：

10.1016/j.ijpharm.2008.10.013

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The surfaces of ibuprofen particles (d(50) 42 mu m) were modified by coating the particles with diluted aqueous hydroxypropyl methylcellulose (HPMC) solution in an instrumentated top-spray fluid bed granulator. The objective was to evaluate whether an extremely thin polymer coating could be an alternative to granulation in enhancing powder flow and processing properties. The studied variables were inlet air temperature and spray rate. The treated powders showed a clear improvement in flow rate as measured with a flow meter designed for powders with poor flow properties. The particle size was determined using optical microscopy and image analysis. The particle size, size distribution and circularity of the treated and untreated ibuprofen batches showed no difference from each other. Consequently. the improvement in flow properties can be attributed to the trace amounts of hydroxypropyl methylcellulose applied onto the particle surfaces. In conclusion, fluidized bed particle thin-coating (PTC) alters the surface of ibuprofen powder particles and improves the flow properties of ibuprofen powder with changes in neither particle size, size distribution nor morphology. (C) 2008 Elsevier B.V. All rights reserved.

引用

页码：165 / 170

页数：6

共 44 条

[1]

ALDERBORN G, 1982, ACTA PHARM SUEC, V19, P381

[2] Excipients for direct compaction - an update [J].

Bolhuis, GK ;

Armstrong, NA .

PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY, 2006, 11 (01) :111-124

[3]

BOLTON S, 1990, PHARM STAT PRACTICAL, P262

[4] The prediction of variability occurring in fluidized bed coating equipment. I. The measurement of particle circulation rates in a bottom-spray fluidized bed coater [J].

Cheng, XX ;

Turton, R .

PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY, 2000, 5 (03) :311-322

[5] Analysis of particle coating by spouted bed process [J].

deOliveira, WP ;

Freire, JT ;

Coury, JR .

INTERNATIONAL JOURNAL OF PHARMACEUTICS, 1997, 158 (01) :1-9

[6]

Dewettinck K, 1998, FOOD SCI TECHNOL-LEB, V31, P576

[7] Influence of polymeric suspension characteristics on the particle coating in a spouted bed [J].

Donida, MW ;

Rocha, SCS ;

Bartholomeu, F .

DRYING TECHNOLOGY, 2005, 23 (9-11) :1811-1823

[8] Coating of urea with an aqueous polymeric suspension in a two-dimensional spouted bed [J].

Donida, MW ;

Rocha, SCS .

DRYING TECHNOLOGY, 2002, 20 (03) :685-704

[9] In situ coating -: An approach for particle modification and encapsulation of proteins during spray-drying [J].

Elversson, Jessica ;

Millqvist-Fureby, Anna .

INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2006, 323 (1-2) :52-63

[10] Effect of moisture and magnesium stearate concentration on flow properties of cohesive granular materials [J].

Faqih, Abdul Mobeen N. ;

Mehrotra, Amit ;

Hammond, Stephen V. ;

Muzzio, Femando J. .

INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2007, 336 (02) :338-345

← 1 2 3 4 5 →