Multinucleation Is an Objective Feature Useful in the Diagnosis of Pleomorphic Lobular Carcinoma In Situ

被引：6

作者：

Blanco, Luis Z. ^{[1
]}

Thurow, Tiffany A. ^{[1
]}

Mahajan, Aparna ^{[1
]}

Susnik, Barbara ^{[2
]}

Helenowski, Irene ^{[3
]}

Chmiel, Joan S. ^{[3
]}

Sullivan, Megan E. ^{[1
]}

机构：

[1] Northwestern Univ, Feinberg Sch Med, Dept Pathol, Chicago, IL 60611 USA

[2] Abbott NW Hosp, Dept Pathol, Minneapolis, MN USA

[3] Northwestern Univ, Feinberg Sch Med, Dept Prevent Med, Chicago, IL 60611 USA

来源：

AMERICAN JOURNAL OF CLINICAL PATHOLOGY | 2015年 / 144卷 / 05期

关键词：

Binucleation; Multinucleation; Lobular carcinoma in situ; Pleomorphic; Ductal carcinoma in situ; E-CADHERIN EXPRESSION; FOLLOW-UP; BREAST; NEOPLASIA; BIOPSY; GRADE; HYPERPLASIA; MORPHOLOGY; INVASION; EXCISION;

D O I：

10.1309/AJCPZHZ2TUE2UYNV

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

Objectives: Bi- and multinucleated (B/M) cells are present in a variety of tumors. We evaluated lobular carcinoma in situ (classic and pleomorphic types) and ductal carcinoma in situ (DCIS) to determine if this objective morphologic feature aids the differential diagnosis. Methods: The number of B/M cells was recorded in pleomorphic lobular carcinoma in situ (PLCIS) (n = 20), classic lobular carcinoma in situ (CLCIS) (n = 26), and DCIS (n = 37). Results: Binucleated cells were significantly more frequent in PLCIS (100%) vs DCIS (43%; P < .0001) and CLCIS (54%; P = .0004). Multinucleated cells were present in 25% of PLCIS cases and 8% of DCIS cases, and they were absent in CLCIS. The quantity of B/M per high-power field (hpf) was less in DCIS (mean, 1.1) and CLCIS (mean, 2.5) compared with PLCIS (mean, 5.8). Thirty-five percent of PLCIS cases had more than five B/M per hpf. Conclusions: Binucleated cells are significantly more frequent in PLCIS vs CLCIS and DCIS. Multinucleated cells were never identified in CLCIS. PLCIS should be considered as a diagnosis when B/M is noted

引用

页码：722 / 726

页数：5

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