Sublingual immunotherapy for allergic rhinitis: where are we now?

被引:3
作者
Incorvaia, Cristoforo [1 ]
Mauro, Marina [2 ]
Ridolo, Erminia [3 ]
机构
[1] ICP Hosp, Allergy Pulm Rehabil, I-20100 Milan, Italy
[2] St Anna Hosp, Allergy Unit, Como, Italy
[3] Univ Parma, Dept Clin & Expt Med, I-43100 Parma, Italy
关键词
allergen immunotherapy; allergic rhinitis; cost-effectiveness; efficacy; quality of allergen extracts; safety; sublingual immunotherapy; 5-GRASS POLLEN TABLET; RANDOMIZED CONTROLLED-TRIAL; SUBCUTANEOUS IMMUNOTHERAPY; SWALLOW IMMUNOTHERAPY; DOUBLE-BLIND; SAFETY; EFFICACY; CHILDREN; PLACEBO; TOLERABILITY;
D O I
10.2217/imt.15.72
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Sublingual immunotherapy (SLIT) was introduced in the 1980s as a safer option to subcutaneous immunotherapy and in the latest decade achieved significant advances. Its efficacy in allergic rhinitis is supported by a number of meta-analyses. The development of SLIT preparations in tablets to fulfill the requirements of regulatory agencies for quality of allergen extracts made available optimal products for grass-pollen-induced allergic rhinitis. Preparations of other allergens based on the same production methods are currently in progress. A notable outcome of SLIT, that is shared with subcutaneous immunotherapy, is the evident cost-effectiveness, showing significant cost savings as early as 3 months from starting the treatment, that become as high as 80% compared with drug treatment in the ensuing years.
引用
收藏
页码:1105 / 1110
页数:6
相关论文
共 57 条
[1]   Injection allergen immunotherapy for asthma [J].
Abramson, Michael J. ;
Puy, Robert M. ;
Weiner, John M. .
COCHRANE DATABASE OF SYSTEMATIC REVIEWS, 2010, (08)
[2]   Standards for practical allergen-specific immunotherapy [J].
Alvarez-Cuesta, E. ;
Bousquet, J. ;
Canonica, G. W. ;
Durham, S. R. ;
Mailing, H. -J. ;
Valovirta, E. .
ALLERGY, 2006, 61 :1-20
[3]   Anaphylaxis caused by allergen sublingual immunotherapy? [J].
Andre, C. ;
Fadel, R. .
ALLERGY, 2007, 62 (10) :1220-1221
[4]  
[Anonymous], 1986, Br Med J (Clin Res Ed), V293, P948
[5]  
[Anonymous], 2007, COCHRANE DB SYST REV
[6]   Long-term adherence to sublingual therapy: literature review and suggestions for management strategies based on patients' needs and preferences [J].
Antico, A. .
CLINICAL AND EXPERIMENTAL ALLERGY, 2014, 44 (11) :1314-1326
[7]  
Bahceciler NN, 2013, IMMUNOTHERAPY-UK, V5, P183, DOI [10.2217/IMT.12.161, 10.2217/imt.12.161]
[8]   Economic studies of immunotherapy: a review [J].
Berto, Patrizia ;
Frati, Franco ;
Incorvaia, Cristoforo .
CURRENT OPINION IN ALLERGY AND CLINICAL IMMUNOLOGY, 2008, 8 (06) :585-589
[9]   Anaphylactic shock because of sublingual immunotherapy overdose during third year of maintenance dose [J].
Blazowski, L. .
ALLERGY, 2008, 63 (03) :374-374
[10]   Allergen immunotherapy: Therapeutic vaccines for allergic diseases - A WHO position paper [J].
Bousquet, J ;
Lockey, R ;
Malling, HJ .
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 1998, 102 (04) :558-562