Hydrogel design strategies for drug delivery

被引：236

作者：

Dreiss, Cecile A. ^{[1
]}

机构：

[1] Kings Coll London, Inst Pharmaceut Sci, 150 Stamford St, London SE1 9NH, England

来源：

CURRENT OPINION IN COLLOID & INTERFACE SCIENCE | 2020年 / 48卷

关键词：

Hydrogels; Drug delivery; Supramolecular gels; Controlled release; Smart gels; Microneedles; 3D printing; NEAR-INFRARED LIGHT; SELF-HEALING HYDROGELS; TRIGGERED DRUG; CONTROLLED-RELEASE; SUPRAMOLECULAR HYDROGELS; RESPONSIVE HYDROGELS; INJECTABLE HYDROGELS; SOFT NANOCOMPOSITES; NANOPARTICLES; MICROGELS;

D O I：

10.1016/j.cocis.2020.02.001

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

Hydrogels are water-swollen three-dimensional networks made of polymers, proteins, small molecules or colloids. They constitute a versatile platform for drug delivery because of their capacity to encapsulate and protect drugs and provide sustained and/or remotely programmable spatial and temporal release and have thus generated a substantial amount of research for the delivery of either small active compounds or biopharmaceuticals. This article discusses the features that make hydrogels attractive as matrices for delivery and reviews a range of designs, focussing on studies from recent years, in particular: 'smart' hydrogels (responding to temperature, light, magnetic fields, ultrasounds or combined stimuli); recent technologies: 3D printing and microneedles; and closes by discussing polymer-free drug delivery systems: peptides, small molecules and colloids.

引用

页码：1 / 17

页数：17

共 119 条

[1] Bright conjugated polymer nanoparticles containing a biodegradable shell produced at high yields and with tuneable optical properties by a scalable microfluidic device [J].

Abelha, T. F. ;

Phillips, T. W. ;

Bannock, J. H. ;

Nightingale, A. M. ;

Dreiss, C. A. ;

Kemal, E. ;

Urbano, L. ;

deMello, J. C. ;

Green, M. ;

Dailey, L. A. .

NANOSCALE, 2017, 9 (05) :2009-2019

[2] Conjugated polymers as nanoparticle probes for fluorescence and photoacoustic imaging [J].

Abelha, Thais Fedatto ;

Dreiss, Cecile A. ;

Green, Mark A. ;

Dailey, Lea Ann .

JOURNAL OF MATERIALS CHEMISTRY B, 2020, 8 (04) :592-606

[3] Low molecular weight PEG-PLGA polymers provide a superior matrix for conjugated polymer nanoparticles in terms of physicochemical properties, biocompatibility and optical/photoacoustic performance [J].

Abelha, Thais Fedatto ;

Neumann, Paul Robert ;

Holthof, Joost ;

Dreiss, Cecile A. ;

Alexander, Cameron ;

Green, Mark ;

Dailey, Lea Ann .

JOURNAL OF MATERIALS CHEMISTRY B, 2019, 7 (33) :5115-5124

[4] Functional Microgels: Recent Advances in Their Biomedical Applications [J].

Agrawal, Garima ;

Agrawal, Rahul .

SMALL, 2018, 14 (39)

[5] Ophthalmic gels: Past, present and future [J].

Al-Kinani, Ali A. ;

Zidan, Ghada ;

Elsaid, Naba ;

Seyfoddin, Ali ;

Alani, Adam W. G. ;

Alany, Raid G. .

ADVANCED DRUG DELIVERY REVIEWS, 2018, 126 :113-126

[6] A pure magnetite hydrogel: synthesis, properties and possible applications [J].

Anastasova, Elizaveta I. ;

Ivanovski, Vladimir ;

Fakhardo, Anna F. ;

Lepeshkin, Artem I. ;

Omar, Suheir ;

Drozdov, Andrey S. ;

Vinogradov, Vladimir V. .

SOFT MATTER, 2017, 13 (45) :8651-8660

[7]

[Anonymous], 2019, ADV HEALTHC MAT

[8]

[Anonymous], SMALL

[9] Near-infrared light-responsive alginate hydrogels based on diselenide-containing cross-linkage for on demand degradation and drug release [J].

Anugrah, Daru Seto Bagus ;

Ramesh, Kaylan ;

Kim, Mingeun ;

Hyun, Kyu ;

Lim, Kwon Taek .

CARBOHYDRATE POLYMERS, 2019, 223

[10] In situ depot formation of anti-HIV fusion-inhibitor peptide in recombinant protein polymer hydrogel [J].

Asai, Daisuke ;

Kanamoto, Taisei ;

Takenaga, Mitsuko ;

Nakashima, Hideki .

ACTA BIOMATERIALIA, 2017, 64 :116-125

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