Oncolytic Adenoviruses: Strategies for Improved Targeting and Specificity

被引：20
作者：
Hajeri, Praveensingh B. [1 ]
Sharma, Nikita S. [1 ]
Yamamoto, Masato [1 ,2 ,3 ]
机构：
[1] Univ Minnesota, Dept Surg, Div Basic & Translat Res, 420 Delaware St SE, Minneapolis, MN 55455 USA
[2] Univ Minnesota, Masonic Canc Ctr, Minneapolis, MN 55455 USA
[3] Univ Minnesota, Stem Cell Inst, Minneapolis, MN 55455 USA
来源：
CANCERS | 2020年 / 12卷 / 06期
关键词：
adenovirus vector; oncolytic adenovirus; library; targeting; promoter; screening; CONDITIONALLY-REPLICATIVE ADENOVIRUS; GENE-TRANSFER EFFICIENCY; GROWTH-FACTOR RECEPTOR; SENECA VALLEY VIRUS; ANTITUMOR EFFICACY; CANCER-CELLS; FIBER KNOB; RNA INTERFERENCE; RETINOBLASTOMA PROTEIN; THERAPEUTIC WINDOW;
D O I：
10.3390/cancers12061504
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Cancer is a major health problem. Most of the treatments exhibit systemic toxicity, as they are not targeted or specific to cancerous cells and tumors. Adenoviruses are very promising gene delivery vectors and have immense potential to deliver targeted therapy. Here, we review a wide range of strategies that have been tried, tested, and demonstrated to enhance the specificity of oncolytic viruses towards specific cancer cells. A combination of these strategies and other conventional therapies may be more effective than any of those strategies alone.
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页码：1 / 26
页数：27
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