Anti-oncogenic potential of the eIF4E-binding proteins

被引：78

作者：

Martineau, Y. ^{[1
]}

Azar, R. ^{[1
,2
]}

Bousquet, C. ^{[1
]}

Pyronnet, S. ^{[1
,3
]}

机构：

[1] Univ Toulouse, CRCT, INSERM UMR 1037, F-31432 Toulouse, France

[2] Lebanese Univ, Fac Pharm, Dept Clin Pharm, Hadath, Lebanon

[3] Ctr Hosp Toulouse, Toulouse, France

来源：

ONCOGENE | 2013年 / 32卷 / 06期

关键词：

protein synthesis; elF4E; 4E-BP; mTOR; INITIATION-FACTOR; 4E; CAP-DEPENDENT TRANSLATION; FACTOR 4E-BINDING PROTEIN-1; SERINE/THREONINE KINASE PIM-2; SMALL-MOLECULE INHIBITION; REPRESSOR PHAS-I; MESSENGER-RNA; BINDING PROTEIN; EIF4E PHOSPHORYLATION; MAMMALIAN TARGET;

D O I：

10.1038/onc.2012.116

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The elF4E-binding proteins (4E-BPs) are inhibitors of protein synthesis that sequester the mRNA cap-binding protein elF4E and consequently block cell growth and proliferation. In most tumors however, their inhibitory function is compromised by major oncogenic signaling pathways. Recently, thanks to the generation of mouse genetic models, considerable progress has been made in elucidating the involvement of 4E-BPs and their unique target, elF4E, in the process of carcinogenesis. Increasing evidence indicates that an 'addiction' to protein synthesis emerges in cancer cells, highlighting the potential that 4E-BPs have as targets for therapeutics. In this review, we summarize the biochemical function, regulation and anti-oncogenic activity of the 4E-BPs. Oncogene (2013) 32, 671-677; doi:10.1038/onc.2012.116; published online 16 April 2012

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收藏

页码：671 / 677

页数：7

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