Recent advances in dual-emission ratiometric fluorescence probes for chemo/biosensing and bioimaging of biomarkers

被引：447
作者：
Gui, Rijun [1 ]
Jin, Hui [1 ]
Bu, Xiangning [1 ]
Fu, Yongxin [1 ]
Wang, Zonghua [1 ]
Liu, Qingyun [2 ]
机构：
[1] Qingdao Univ, Coll Chem & Chem Engn, Shandong Sino Japanese Ctr Collaborat Res Carbon, Qingdao 266071, Peoples R China
[2] Shandong Univ Sci & Technol, Coll Chem & Environm Engn, Qingdao 266590, Peoples R China
来源：
COORDINATION CHEMISTRY REVIEWS | 2019年 / 383卷
基金：
中国国家自然科学基金;
关键词：
Ratiometric fluorescence; Visual detection; Bioimaging; Biosensors; Biomarkers; HIGHLY SELECTIVE DETECTION; PAPER-BASED PLATFORM; QUANTUM DOTS; ANTHRAX BIOMARKER; CARBON DOTS; SENSITIVE DETECTION; ALKALINE-PHOSPHATASE; OXIDATIVE STRESS; ENERGY-TRANSFER; LIVING CELLS;
D O I：
10.1016/j.ccr.2019.01.004
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
A biomarker-based detection improves early diagnosis and subsequent treatment of diseases. Chemo/biosensing and bioimaging play a crucial role in biomarker detection. Ratiometric fluorescence (FL) probes provide built-in self-calibration for the correction of various target-independent factors and attract particular attention for analytical sensing and optical imaging. Based on the potential to provide a precise, quantitative, visual and real-time analysis, ratiometric FL probes are widely employed for chemo/biosensing and bioimaging detection of biomarkers. In this review, we systematically summarize the recent progress on dual-emission ratiometric FL probes. First, two general categories of ratiometric FL probes are introduced, involving ratiometric FL with one reference signal and two reversible signal changes. Then, fabrication methods of ratiometric FL probes are summarized in detail, including nanoparticle- or organic dye-embedded probes with dual-emission FL, fluorescent nanoparticles and organic dyes dual-embedded probes. Analytical applications of ratiometric FL probes are described overall, referring to different biomarker types and detection mechanisms, ratiometric FL chemo/biosensing in external samples and FL visual detection, ratiometric FL bioimaging in cells and tissues of small animals. Current states, probable challenges and future perspectives of ratiometric FL probes for biomarker detection are discussed rationally. This comprehensive review is attractive for numerous scientists from different areas, such as material science, chemistry, biomedicine, engineering, physics, etc. This review covers a wide range of scientific disciplines and benefits further development of functionalized optical materials, luminescent devices and bioimaging technique. (C) 2019 Elsevier B.V. All rights reserved.
引用
收藏
页码：82 / 103
页数：22
相关论文
共 130 条
[1]   Surface plasmon resonance based immunosensor for the detection of the cancer biomarker carcinoembryonic antigen [J].
Altintas, Zeynep ;
Uludag, Yildiz ;
Gurbuz, Yasar ;
Tothill, Ibtisam E. .
TALANTA, 2011, 86 :377-383
[2]   Beyond graphene: Electrochemical sensors and biosensors for biomarkers detection [J].
Bollella, Paolo ;
Fusco, Giovanni ;
Tortolini, Cristina ;
Sanzo, Gabriella ;
Favero, Gabriele ;
Gorton, Lo ;
Antiochia, Riccarda .
BIOSENSORS & BIOELECTRONICS, 2017, 89 :152-166
[3]   Ratiometric fluorescence biosensor based on DNA/miRNA duplex@CdTe QDs and oxidized luminol as a fluorophore for miRNA detection [J].
Borghei, Yasaman Sadat ;
Hosseini, Morteza .
JOURNAL OF LUMINESCENCE, 2018, 204 :16-23
[4]   Specific enzymatic synthesis of 2,3-diaminophenazine and copper nanoclusters used for dual-emission ratiometric and naked-eye visual fluorescence sensing of choline [J].
Bu, Xiangning ;
Fu, Yongxin ;
Jin, Hui ;
Gui, Rijun .
NEW JOURNAL OF CHEMISTRY, 2018, 42 (21) :17323-17330
[5]   BSA-AuNPs@Tb-AMP metal-organic frameworks for ratiometric fluorescence detection of DPA and Hg2+ [J].
Cai, Keying ;
Zeng, Mulan ;
Liu, Fenfen ;
Liu, Nan ;
Huang, Zhenzhong ;
Song, Yonghai ;
Wang, Li .
LUMINESCENCE, 2017, 32 (07) :1277-1282
[6]   Hybrid 2D-nanomaterials-based electrochemical immunosensing strategies for clinical biomarkers determination [J].
Campuzano, S. ;
Pedrero, M. ;
Nikoleli, G. -P. ;
Pingarron, J. M. ;
Nikolelis, D. P. .
BIOSENSORS & BIOELECTRONICS, 2017, 89 :269-279
[7]   Dual core quantum dots for highly quantitative ratiometric detection of trypsin activity in cystic fibrosis patients [J].
Castello Serrano, Ivan ;
Stoica, Georgiana ;
Matas Adams, Alba ;
Palomares, Emilio .
NANOSCALE, 2014, 6 (22) :13623-13629
[8]   Phospholipid-Modified Upconversion Nanoprobe for Ratiometric Fluorescence Detection and Imaging of Phospholipase D in Cell Lysate and in Living Cells [J].
Cen, Yao ;
Wu, Yan-Mei ;
Kong, Xiang-Juan ;
Wu, Shuang ;
Yu, Ru-Qin ;
Chu, Xia .
ANALYTICAL CHEMISTRY, 2014, 86 (14) :7119-7127
[9]   A ratiometric fluorescent nanoprobe based on terbium functionalized carbon dots for highly sensitive detection of an anthrax biomarker [J].
Chen, Hao ;
Xie, Yujie ;
Kirillov, Alexander M. ;
Liu, Liangliang ;
Yu, Minghui ;
Liu, Weisheng ;
Tang, Yu .
CHEMICAL COMMUNICATIONS, 2015, 51 (24) :5036-5039
[10]   A sensitive ratiometric fluorescence probe for chymotrypsin activity and inhibitor screening [J].
Chen, Yiping ;
Cao, Jing ;
Jiang, Xiaoxue ;
Pan, Zhizhen ;
Fu, Nanyan .
SENSORS AND ACTUATORS B-CHEMICAL, 2018, 273 :204-210
12345678910