Delayed upregulation of GABAA alpha1 receptor subunit mRNA in somatosensory cortex of mice following learning-dependent plasticity of cortical representations

被引：23

作者：

Lech, M ^{[1
]}

Skibinska, A ^{[1
]}

Kossut, M ^{[1
]}

机构：

[1] M Nencki Inst Expt Biol, Dept Neurophysiol, PL-02093 Warsaw, Poland

来源：

MOLECULAR BRAIN RESEARCH | 2001年 / 96卷 / 1-2期

关键词：

GABA receptor; mRNA expression; barrel cortex; learning; mouse;

D O I：

10.1016/S0169-328X(01)00271-6

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Experience-dependent modifications of cortical representational maps are accompanied by changes in several components of GABAergic inhibitory neurotransmission system. We examined with in situ hybridization to S-35-labeled oligoprobe changes of expression of GABA,, receptor alpha1 subunit mRNA in the barrel cortex of mice after sensory conditioning training. One day and 5 days after the end of short lasting (3 daily sessions) training an increased expression of GABA(A), alpha1 mRNA was observed at the cortical site where the plastic changes were previously found. Learning associated activation of the cerebral cortex increases expression of GABA(A) receptor mRNA after a short post-training delays. (C) 2001 Elsevier Science BY. All rights reserved.

引用

页码：82 / 86

页数：5

共 29 条

[21] CONTRIBUTION OF INHIBITORY MECHANISMS TO RECEPTIVE-FIELD PROPERTIES OF NEURONS IN STRIATE CORTEX OF CAT [J].

SILLITO, AM .

JOURNAL OF PHYSIOLOGY-LONDON, 1975, 250 (02) :305-329

[22] Short-lasting classical conditioning induces reversible changes of representational maps of vibrissae in mouse SI cortex - A 2DG study [J].

Siucinska, E ;

Kossut, M .

CEREBRAL CORTEX, 1996, 6 (03) :506-513

[23] GABA immunoreactivity in mouse barrel field after aversive and appetitive classical conditioning training involving facial vibrissae [J].

Siucinska, E ;

Kossut, M ;

Stewart, MG .

BRAIN RESEARCH, 1999, 843 (1-2) :62-70

[24]

SKANGIELKRAMSKA J, 1984, ACTA NEUROBIOL EXP, V44, P33

[25] REDUCTION OF GABA(A) RECEPTOR-BINDING OF [H-3] MUSCIMOL IN THE BARREL FIELD OF MICE AFTER PERIPHERAL DENERVATION - TRANSIENT AND LONG-LASTING EFFECTS [J].

SKANGIELKRAMSKA, J ;

GLAZEWSKI, S ;

JABLONSKA, B ;

SIUCINSKA, E ;

KOSSUT, M .

EXPERIMENTAL BRAIN RESEARCH, 1994, 100 (01) :39-46

[26] GABA(A) receptor subunits in the rat hippocampus .3. Altered messenger RNA expression in kainic acid-induced epilepsy [J].

Tsunashima, K ;

Schwarzer, C ;

Kirchmair, E ;

Sieghart, W ;

Sperk, G .

NEUROSCIENCE, 1997, 80 (04) :1019-1032

[27] PLASTICITY IN THE BARREL CORTEX OF THE ADULT-MOUSE - TRANSIENT INCREASE OF GAD-IMMUNOREACTIVITY FOLLOWING SENSORY STIMULATION [J].

WELKER, E ;

SORIANO, E ;

DORFL, J ;

VANDERLOOS, H .

EXPERIMENTAL BRAIN RESEARCH, 1989, 78 (03) :659-664

[28]

WISDEN W, 1994, IN SITU HYBRIDIZATIO, P9

[29] STRUCTURAL ORGANIZATION OF LAYER-IV IN SOMATOSENSORY REGION (SI) OF MOUSE CEREBRAL CORTEX . DESCRIPTION OF A CORTICAL FIELD COMPOSED OF DISCRETE CYTOARCHITECTONIC UNITS [J].

WOOLSEY, TA ;

VANDERLO.H .

BRAIN RESEARCH, 1970, 17 (02) :205-+

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