Common Carotid Intima-Media Thickness Measurements in Cardiovascular Risk Prediction A Meta-analysis

被引：588

作者：

Den Ruijter, Hester M. ^{[1
,2
]}

Peters, Sanne A. E. ^{[1
]}

Anderson, Todd J. ^{[3
,4
]}

Britton, Annie R. ^{[5
]}

Dekker, Jacqueline M. ^{[6
]}

Eijkemans, Marinus J. ^{[1
]}

Engstrom, Gunnar ^{[7
]}

Evans, Gregory W. ^{[8
]}

de Graaf, Jacqueline ^{[9
]}

Grobbee, Diederick E. ^{[1
,10
]}

Hedblad, Bo ^{[7
]}

Hofman, Albert ^{[11
]}

Holewijn, Suzanne ^{[9
]}

Ikeda, Ai ^{[12
]}

Kavousi, Maryam ^{[11
]}

Kitagawa, Kazuo ^{[13
]}

Kitamura, Akihiko ^{[12
]}

Koffijberg, Hendrik ^{[1
]}

Lonn, Eva M. ^{[14
,15
]}

Lorenz, Matthias W. ^{[16
]}

Mathiesen, Ellisiv B. ^{[17
]}

Nijpels, Giel ^{[6
]}

Okazaki, Shuhei ^{[13
]}

O'Leary, Daniel H. ^{[18
]}

Polak, Joseph F. ^{[18
]}

Price, Jackie F. ^{[19
]}

Robertson, Christine ^{[19
]}

Rembold, Christopher M. ^{[20
]}

Rosvall, Maria ^{[7
]}

Rundek, Tatjana ^{[21
]}

Salonen, Jukka T. ^{[22
]}

Sitzer, Matthias ^{[16
,23
]}

Stehouwer, Coen D. A. ^{[24
,25
]}

Witteman, Jacqueline C. ^{[11
]}

Moons, Karel G. ^{[1
]}

Bots, Michiel L. ^{[1
]}

机构：

[1] Univ Med Ctr Utrecht, Julius Ctr Hlth Sci & Primary Care, NL-3584 CX Utrecht, Netherlands

[2] Univ Med Ctr Utrecht, Dept Expt Cardiol, NL-3584 CX Utrecht, Netherlands

[3] Univ Calgary, Dept Cardiac Sci, Calgary, AB, Canada

[4] Univ Calgary, Libin Cardiovasc Inst Alberta, Calgary, AB, Canada

[5] UCL, Dept Epidemiol & Publ Hlth, London, England

[6] Vrije Univ Amsterdam Med Ctr, Inst Hlth & Care Res, Amsterdam, Netherlands

[7] Lund Univ, Dept Clin Sci Malmo, Skane Univ Hosp, Malmo, Sweden

[8] Wake Forest Sch Med, Dept Biostat Sci & Neurol, Winston Salem, NC USA

[9] Univ Nijmegen, Med Ctr, Dept Gen Internal Med, Div Vasc Med, Nijmegen, Netherlands

[10] Univ Malaya, Med Ctr, Kuala Lumpur, Malaysia

[11] Erasmus MC, Dept Epidemiol, Rotterdam, Netherlands

[12] Osaka Med Ctr Hlth Sci & Promot, Osaka, Japan

[13] Osaka Univ, Stroke Ctr, Dept Neurol, Grad Sch Med, Osaka, Japan

[14] McMaster Univ, Dept Med, Div Cardiol, Hamilton, ON, Canada

[15] McMaster Univ, Populat Hlth Res Inst, Hamilton, ON, Canada

[16] Goethe Univ Frankfurt, Dept Neurol, Univ Hosp, Frankfurt, Germany

[17] Univ Tromso, Inst Clin Med, Brain & Circulat Res Grp, Tromso, Norway

[18] Tufts Med Ctr, Dept Radiol, Boston, MA USA

[19] Univ Edinburgh, Ctr Populat Hlth Sci, Edinburgh, Midlothian, Scotland

[20] Univ Virginia, Dept Internal Med, Div Cardiol, Charlottesville, VA USA

[21] Univ Miami, Miller Sch Med, Dept Neurol, Miami, FL 33136 USA

[22] MAS Metab Analyt Serv Oy, Helsinki, Finland

[23] Klinikum Herford, Dept Neurol, Herford, Germany

[24] Maastricht Univ, Med Ctr, Dept Internal Med, Maastricht, Netherlands

[25] Maastricht Univ, Med Ctr, Cardiovasc Res Inst Maastricht, Maastricht, Netherlands

来源：

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION | 2012年 / 308卷 / 08期

基金：

美国国家卫生研究院;

关键词：

CORONARY-HEART-DISEASE; TASK-FORCE; ATHEROSCLEROSIS PROGRESSION; GENERAL-POPULATION; ARTERY-DISEASE; PLAQUE; EVENTS; ASSOCIATION; MEN; GUIDELINES;

D O I：

10.1001/jama.2012.9630

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Context The evidence that measurement of the common carotid intima-media thickness (CIMT) improves the risk scores in prediction of the absolute risk of cardiovascular events is inconsistent. Objective To determine whether common CIMT has added value in 10-year risk prediction of first-time myocardial infarctions or strokes, above that of the Framingham Risk Score. Data Sources Relevant studies were identified through literature searches of databases (PubMed from 1950 to June 2012 and EMBASE from 1980 to June 2012) and expert opinion. Study Selection Studies were included if participants were drawn from the general population, common CIMT was measured at baseline, and individuals were followed up for first-time myocardial infarction or stroke. Data Extraction Individual data were combined into 1 data set and an individual participant data meta-analysis was performed on individuals without existing cardiovascular disease. Results We included 14 population-based cohorts contributing data for 45 828 individuals. During a median follow-up of 11 years, 4007 first-time myocardial infarctions or strokes occurred. We first refitted the risk factors of the Framingham Risk Score and then extended the model with common CIMT measurements to estimate the absolute 10-year risks to develop a first-time myocardial infarction or stroke in both models. The C statistic of both models was similar (0.757; 95% CI, 0.749-0.764; and 0.759; 95% CI, 0.752-0.766). The net reclassification improvement with the addition of common CIMT was small (0.8%; 95% CI, 0.1%-1.6%). In those at intermediate risk, the net reclassification improvement was 3.6% in all individuals (95% CI, 2.7%-4.6%) and no differences between men and women. Conclusion The addition of common CIMT measurements to the Framingham Risk Score was associated with small improvement in 10-year risk prediction of first-time myocardial infarction or stroke, but this improvement is unlikely to be of clinical importance. JAMA. 2012;308(8):796-803 www.jama.com

引用

页码：796 / 803

页数：8

共 45 条

[1] Preventing myocardial infarction in the young adult in the first place: How do the National Cholesterol Education Panel III guidelines perform? [J].

Akosah, KO ;

Schaper, A ;

Cogbill, C ;

Schoenfeld, P .

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2003, 41 (09) :1475-1479

[2] Prediction of major adverse cardiovascular events by age-normalized carotid intimal medial thickness [J].

Ali, Yasmine S. ;

Rembold, Karen E. ;

Weaver, Brad ;

Wills, Mary Beth ;

Tatar, Steven ;

Ayers, Carlos R. ;

Rembold, Christopher M. .

ATHEROSCLEROSIS, 2006, 187 (01) :186-190

[3] Relationship between carotid intima-media thickness and symptomatic and asymptomatic peripheral arterial disease - The Edinburgh Artery Study [J].

Allan, PL ;

Mowbray, PI ;

Lee, AJ ;

Fowkes, FGR .

STROKE, 1997, 28 (02) :348-353

[4] Microvascular Function Predicts Cardiovascular Events in Primary Prevention Long-Term Results From the Firefighters and Their Endothelium (FATE) Study [J].

Anderson, Todd J. ;

Charbonneau, Francois ;

Title, Lawrence M. ;

Buithieu, Jean ;

Rose, M. Sarah ;

Conradson, Heather ;

Hildebrand, Kathy ;

Fung, Marinda ;

Verma, Subodh ;

Lonn, Eva M. .

CIRCULATION, 2011, 123 (02) :163-169

[5] Appropriate use criteria for carotid intima media thickness testing [J].

不详 .

ATHEROSCLEROSIS, 2011, 214 (01) :43-46

[6] Screening for Cardiovascular Risk in Asymptomatic Patients [J].

Berger, Jeffrey S. ;

Jordan, Courtney O. ;

Lloyd-Jones, Donald ;

Blumenthal, Roger S. .

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2010, 55 (12) :1169-1177

[7] Left, right, near or far wall common carotid intima-media thickness measurements: Associations with cardiovascular disease and lower extremity arterial atherosclerosis [J].

Bots, ML ;

deJong, PTVM ;

Hofman, A ;

Grobbee, DE .

JOURNAL OF CLINICAL EPIDEMIOLOGY, 1997, 50 (07) :801-807

[8] Common carotid intima media thickness as an indicator of atherosclerosis at other sites of the carotid artery - The Rotterdam study [J].

Bots, ML ;

Hofman, A ;

deJong, PTVM ;

Grobbee, DE .

ANNALS OF EPIDEMIOLOGY, 1996, 6 (02) :147-153

[9] Association of carotid artery intima-media thickness, plaques, and C-reactive protein with future cardiovascular disease and all-cause mortality - The cardiovascular health study [J].

Cao, Jie J. ;

Arnold, Alice M. ;

Manolio, Teri A. ;

Polak, Joseph F. ;

Psaty, Bruce M. ;

Hirsch, Calvin H. ;

Kuller, Lewis H. ;

Cushman, Mary .

CIRCULATION, 2007, 116 (01) :32-38

[10] Performance of reclassification statistics in comparing risk prediction models [J].

Cook, Nancy R. ;

Paynter, Nina P. .

BIOMETRICAL JOURNAL, 2011, 53 (02) :237-258

← 1 2 3 4 5 →