Supramolecular Nanofibers of Peptide Amphiphiles for Medicine

被引：68
作者：
Webber, Matthew J. [1 ,2 ]
Berns, Eric J. [1 ,2 ]
Stupp, Samuel I. [2 ,3 ,4 ,5 ]
机构：
[1] Northwestern Univ, Dept Biomed Engn, Evanston, IL 60208 USA
[2] Northwestern Univ, Inst BioNanotechnol Med, Chicago, IL 60611 USA
[3] Northwestern Univ, Dept Mat Sci & Engn, Evanston, IL 60208 USA
[4] Northwestern Univ, Dept Chem, Evanston, IL 60208 USA
[5] Northwestern Univ, Dept Med, Chicago, IL 60611 USA
来源：
ISRAEL JOURNAL OF CHEMISTRY | 2013年 / 53卷 / 08期
基金：
美国国家卫生研究院;
关键词：
amphiphiles; nanostructures; peptides; self-assembly; supramolecular chemistry; SELF-ASSEMBLING NANOFIBERS; ANTITUMOR-ACTIVITY; BONE REGENERATION; SYNTHETIC PEPTIDE; CAVERNOUS NERVE; CELL ATTACHMENT; DRUG-RELEASE; NITRIC-OXIDE; A-CHAIN; MOLECULES;
D O I：
10.1002/ijch.201300046
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Peptide nanostructures are an exciting class of supramolecular systems that can be designed for novel therapies with great potential in advanced medicine. This paper reviews progress on nanostructures based on peptide amphiphiles capable of forming one-dimensional assemblies that emulate in structure the nanofibers present in extracellular matrices. These systems are highly tunable using supramolecular chemistry, and can be designed to signal cells directly with bioactive peptides. Peptide amphiphile nanofibers can also be used to multiplex functions through co-assembly and designed to deliver proteins, nucleic acids, drugs, or cells. We illustrate here the functionality of these systems, describing their use in regenerative medicine of bone, cartilage, the nervous system, the cardiovascular system, and other tissues. In addition, we highlight recent work on the use of peptide amphiphile assemblies to create hierarchical biomimetic structures with order beyond the nanoscale, and also discuss the future prospects of these supramolecular systems.
引用
收藏
页码：530 / 554
页数：25
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