Optimization of vagus nerve stimulation parameters using the firing activity of serotonin neurons in the rat dorsal raphe

被引：35
作者：
Manta, Stella [1 ]
Dong, Jianming [2 ]
Debonnel, Guy [2 ]
Blier, Pierre [1 ,2 ]
机构：
[1] Univ Ottawa, Mental Hlth Res Inst, Ottawa, ON K1Z 7K4, Canada
[2] McGill Univ, Dept Psychiat, Montreal, PQ H3A 1A1, Canada
来源：
EUROPEAN NEUROPSYCHOPHARMACOLOGY | 2009年 / 19卷 / 04期
关键词：
Vagus nerve stimulation (VNS); Stimulation parameters; Serotonin; Electrophysiology; Depression; TREATMENT-RESISTANT DEPRESSION; LOCUS-COERULEUS; THERAPY; EPILEPSY; SEIZURES; VNS; SUPPRESSION; INHIBITION; EFFICACY; SAFETY;
D O I：
10.1016/j.euroneuro.2008.12.001
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Vagus nerve stimulation (VNS) is a recently approved adjunctive intervention for treatment-resistant depression. This therapy enhances the firing rate of rat norepinephrine neurons after 1 h and that of serotonin (5-HT) neurons only after 14 days. Various stimulation parameters were thus tested on their capacity to enhance 5-HT neuronal firing because of the delayed action of VNS on the 5-HT system and its important rote in the antidepressant response. Rats were implanted with a stimulator and treated for 14 days, each group of rats having only one stimulation parameter modified from the standard ones (0.25 mA, 20 Hz, 500 mu s, 30 s ON/5 min OFF). Electrophysiological recordings showed that the usual parameters utilized in depressed patients, with the exception of current intensity, produced an optimal activation of 5-HT neurons. Excessive enhancement of the charge delivered to the nerve can lead to a loss of VNS effect on 5-HT neuronal firing. (c) 2008 Elsevier B.V. and ECNP. All rights reserved.
引用
收藏
页码：250 / 255
页数：6
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