Pharmacokinetic comparison of puerarin after oral administration of Jiawei-Xiaoyao-San to healthy volunteers and patients with functional dyspepsia: influence of disease state

Objectives An investigation has been designed and conducted to compare the pharmacokinetics of puerarin after oral administration of Jiawei-Xiaoyao-San to healthy Volunteers and to patients with functional dyspepsia. Methods Quantification of puerarin in serum was achieved using a simple and rapid HPLC method for pharmacokinetic study. Key findings After oral administration of decoctions of Jiawei-Xiaoyao-San to healthy volunteers and patients with functional dyspepsia, Puerarin was absorbed and reached it maximum concentration of 56.47 +/- 15.60 and 29.40 +/- 8.89 ng/ml at 51.00 +/- 8.22 and 50.00 +/- 12.25 min, respectively. Compared with the value of AUC(0-360) (5.55 +/- 1.47 mu g/ml min) in healthy volunteers', a smaller value of AUC(0-360)) (3.35 +/- 1.17 mu g/ml min) was observed in patients with functional dyspepsia. Conclusions There were statistically significant differences in the pharmacokinetic parameters of puerarin including the values for C-max, AUC(0-360), Cl/F and MRT0-360 between healthy volunteers and patients with functional dyspepsia, The pharmacokinetic parameters showed that functional dyspepsia reduced the absorption Of puerarin after oral administration of Jiawei-Xiaoyao-San.