Prophylactic Efficacy of Oral Emtricitabine and Tenofovir Disoproxil Fumarate Combination Therapy Against a Tenofovir-Resistant Simian/Human Immunodeficiency Virus Containing the K65R Mutation in Macaques

被引：19
作者：
Cong, Mian-er [1 ]
Mitchell, James [1 ]
Sweeney, Elizabeth [1 ]
Bachman, Shanon [1 ]
Hanson, Debra L. [1 ]
Heneine, Walid [1 ]
Garcia-Lerma, J. Gerardo [1 ]
机构：
[1] Ctr Dis Control & Prevent, Branch Lab, Div HIV AIDS Prevent, Natl Ctr HIV AIDS Viral Hepatitis STD & TB Preven, Atlanta, GA USA
来源：
JOURNAL OF INFECTIOUS DISEASES | 2013年 / 208卷 / 03期
基金：
美国国家卫生研究院;
关键词：
Preexposure prophylaxis; HIV-1 drug resistance; tenofovir disoproxil fumarate; emtricitabine; HIV-1; DRUG-RESISTANCE; INTERMITTENT PROPHYLAXIS; TRANSMISSION; PREVENTION; INFECTION; TRUVADA;
D O I：
10.1093/infdis/jit189
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Daily preexposure prophylaxis (PrEP) with emtricitabine/tenofovir disoproxil fumarate (FTC/TDF) is a novel strategy for preventing human immunodeficiency virus infection. We investigated in macaques whether FTC/TDF prevents transmission of a tenofovir-resistant simian/human immunodeficiency virus (SHIV) containing the K65R mutation. Six macaques received weekly a dose of FTC/TDF 3 days before rectal SHIV exposures and a second dose 2 hours after. Six untreated animals were controls. Animals were exposed rectally to escalating virus doses weekly for up to 28 weeks. PrEP significantly delayed infection with SHIVK65R (P = .028), although 4 of 6 FTC/TDF-treated macaques were infected at the end of the challenges. These findings highlight the need to closely monitor PrEP efficacy in areas with prevalent K65R.
引用
收藏
页码：463 / 467
页数：5
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