Comparison of the Growth and Degradation of Poly(glycolic acid) and Poly(ε-caprolactone) Brushes

被引：15

作者：

Hu, Xinfang ^{[1
]}

Hu, Gongfang ^{[1
]}

Crawford, Kaitlyn ^{[1
]}

Gorman, Christopher B. ^{[1
]}

机构：

[1] N Carolina State Univ, Dept Chem, Raleigh, NC 27695 USA

来源：

JOURNAL OF POLYMER SCIENCE PART A-POLYMER CHEMISTRY | 2013年 / 51卷 / 21期

关键词：

degradation; polyesters; ring-opening polymerization; RING-OPENING POLYMERIZATION; POLY(LACTIC ACID); BIODEGRADABLE POLYMERS; EPSILON-CAPROLACTONE; L-LACTIDE; BIOCOMPATIBILITY; LACTONES; DELIVERY; SUTURES; INVITRO;

D O I：

10.1002/pola.26885

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

The growth and degradation of poly(glycolic acid) (PGA) and poly(epsilon-caprolactone) (PCL) brushes were compared. Using tin (octanoate) as the catalyst, optimal conditions were found for growth of each polyester brush from the hydroxy-terminated silicon surface via ring-opening polymerization. PCL brushes grew thicker at elevated temperatures but the thickest PGA brushes grew at room temperature. Unlike bulk polyesters that can degrade under both acidic and basic conditions, the confined surface polyester brushes only degraded under neutral or basic conditions. The degradation mechanism of grafted polyester brushes was probed through a blocking test. It was shown that the terminal hydroxy groups of these polyester brushes were essential to the degradation process indicating a preferential backbiting mechanism. (c) 2013 Wiley Periodicals, Inc. J. Polym. Sci., Part A: Polym. Chem. 2013, 51, 4643-4649

引用

页码：4643 / 4649

页数：7

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