Ultrasonic transport of particles into articular cartilage and subchondral bone

被引：7

作者：

Nieminen, H. J. ^{[1
]}

Herranen, T. ^{[1
]}

Kananen, V. ^{[1
]}

Hacking, S. A.

Salmi, A. ^{[1
]}

Karppinen, P. ^{[1
]}

Haeggstroem, E. ^{[1
]}

机构：

[1] Univ Helsinki, Dept Phys, FIN-00014 Helsinki, Finland

来源：

2012 IEEE INTERNATIONAL ULTRASONICS SYMPOSIUM (IUS) | 2012年

关键词：

OSTEOARTHRITIS;

D O I：

10.1109/ULTSYM.2012.0469

中图分类号：

TM [电工技术]; TN [电子技术、通信技术];

学科分类号：

0808 ; 0809 ;

摘要：

Osteoarthritis (OA) is a debilitating musculoskeletal disease without a cure. Delivery of therapeutic compounds is a problem and localized drug therapy could enable new treatment strategies. In this study high-intensity ultrasound was used to deliver micro-and nano-particles (MNPS) into three bovine osteochondral samples: (1) control (C) that was exposed to the particles without sonication, (2) UST-1 that was sonicated prior to immersion in a MNPS and (3) UST-2 that was sonicated in the presence of MNPS. Following treatment samples were cut into 2.9 +/- 0.3 mm sections and digital images were obtained by light microscopy. In the sonicated samples (UST-1 and UST-2) MNPS penetrated into articular cartilage and subchondral bone. No MNPS penetration was observed in C. The proposed technique could potentially be used for local drug treatment of OA.

引用

页码：1869 / 1872

页数：4

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