Two New Derivatives of 2, 5-Dihydroxyphenyl Acetic Acid from the Kernel of Entada phaseoloides

被引：15
|
作者：
Chen, Lin [1 ,2 ]
Zhang, Yong [1 ,2 ]
Ding, Gang [1 ,2 ]
Ba, Mingyu [3 ,4 ]
Guo, Ying [3 ,4 ]
Zou, Zhongmei [1 ,2 ]
机构：
[1] Chinese Acad Med Sci, Inst Med Plant Dev, Beijing 100193, Peoples R China
[2] Peking Union Med Coll, Beijing 100193, Peoples R China
[3] Chinese Acad Med Sci, Inst Mat Med, Beijing Key Lab New Drug Mech & Pharmacol Evaluat, Beijing 100050, Peoples R China
[4] Peking Union Med Coll, Beijing 100050, Peoples R China
来源：
MOLECULES | 2013年 / 18卷 / 02期
关键词：
Entada phaseoloides; Leguminosae; 2,5-dihydroxyphenyl acetic acid; HIV-1; STEMS;
D O I：
10.3390/molecules18021477
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Two new aromatic compounds, butyl 2,5-dihydroxyphenyl acetate (1) and butyl 2-O-beta-D-glucopyranosyloxy-5-dihydroxyphenyl acetate (2), together with three known ones, methyl 2,5-dihydroxyphenyl acetate (3), ethyl 2,5-dihydroxyphenyl acetate (4) and 2-O-beta-D-glucopyranosyloxy-5-hydroxyphenyl acetic acid (5), were isolated from the EtOH extract of the kernel of Entada phaseoloides. The structures of the new compounds were elucidated by MS and NMR experiments. Compounds 1, 3 and 4 displayed potent inhibitory activities against HIV-1 replication, with EC50 values of 9.80 mu M, 11.70 mu M and 9.93 mu M, respectively.
引用
收藏
页码：1477 / 1482
页数：6
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