Anti-inflammatory Activity of Piper magnibaccum (Piperaceae)

被引：0

作者：

Emrizal ^{[1
]}

Ahmad, Farediah ^{[1
]}

Sirat, Hasnah M. ^{[1
]}

Jamaludin, Fadzureena ^{[2
]}

Mustapha, Nik Musa'adah ^{[2
]}

Ali, Rasadah M. ^{[2
]}

Arbain, Dayar ^{[3
]}

机构：

[1] Univ Teknol Malaysia, Dept Chem, Fac Sci, Skudai 81310, Johor Bahru, Malaysia

[2] FRIM, Kuala Lumpur 52109, Malaysia

[3] Andalas Univ, Dept Pharm, Fac Sci, Padang, Indonesia

来源：

NATURAL PRODUCT COMMUNICATIONS | 2008年 / 3卷 / 10期

关键词：

Sterol; amide; TPA; lipoxygenase; anti-inflammatory activity;

D O I：

暂无

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Anti-inflammatory activity of a crude extract of Piper magnibaccum (Piperaceae) and of compounds isolated from it was established using the TPA-induced mouse ear edema model and an in vitro quantitative lipoxygenase inhibition assay. Five compounds were isolated from P. magnibaccum [beta-sitosterol, N-isobutyl-(2E,4E)-tetradecadienamide, linoleic acid, 13-(4', 5'-dimethoxytridecanoyl)piperidine, and piperine]. The light petroleum extract of the plant exhibited significant anti-inflammatory activity in both models. N-isobutyl-(2E,4E)-tetradecadienamide showed significant activity, with an IE % value of 70.2 +/- 5.4 in the TPA-induced mouse ear edema model and 87.2 +/- 0.11 in the in vitro quantitative lipoxygenase inhibition assay.

引用

页码：1719 / 1721

页数：3

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