Individual pKa Values of Tobramycin, Kanamycin B, Amikacin, Sisomicin, and Netilmicin Determined by Multinuclear NMR Spectroscopy

被引：26

作者：

Alkhzem, Abdulaziz H. ^{[1
]}

Woodman, Timothy J. ^{[1
]}

Blagbrough, Ian S. ^{[1
]}

机构：

[1] Univ Bath, Dept Pharm & Pharmacol, Bath BA2 7AY, Avon, England

来源：

ACS OMEGA | 2020年 / 5卷 / 33期

关键词：

AMINOGLYCOSIDES; ANTIBIOTICS; POLYAMINES; BASE; ACID;

D O I：

10.1021/acsomega.0c02744

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

NMR spectroscopy is a powerful technique for separating and measuring each distinct pK(a) value of the amino groups around aminoglycoside antibiotics. Unambiguous assignments were made for each individual amine substituent on 2-deoxystreptamine, tobramycin, kanamycin B, amikacin, sisomicin, and netilmicin using variations in the NMR spectroscopic chemical shift (delta) with H-1, C-13, and N-15 HMBC; the individual pK(a) values of netilmicin are reported for the first time.

引用

页码：21094 / 21103

页数：10

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