The Role of p53 Protein and MMP-2 Tumor/Stromal Cells Expression on Progressive Growth of Ovarian Neoplasms

被引：24
作者：
Grelewski, Piotr Grzegorz [1 ]
Bar, Julia Krystyna [1 ]
机构：
[1] Wroclaw Med Univ, Dept Pathomorphol & Oncol Cytol, PL-50556 Wroclaw, Poland
来源：
CANCER INVESTIGATION | 2013年 / 31卷 / 07期
关键词：
Ovarian cancer; Immunology/immunobiology; Invasion & metastasis; Molecular biology; MATRIX METALLOPROTEINASE-2; IN-VIVO; METASTASIS; INVASION; CARCINOMA;
D O I：
10.3109/07357907.2013.820320
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The aim of our study was to evaluate p53 gene/protein status and MMP-2 expression in respect to ovarian tumors progress to define the role of these markers in the metastasis of ovarian carcinomas. MMP-2 and p53 alterations were evaluated on 80 malignant, 30 benign ovarian tumors, and 62 metastatic lesions by using HRM method for mutations in p53 gene and by using RT-PCR for mRNA MMP-2 level. Our data indicate that parallel expression of MMP-2 epithelial/stromal cells and p53 may enhance cells invasion and metastasis in ovarian carcinoma.
引用
收藏
页码：472 / 479
页数：8
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