The Role of p53 Protein and MMP-2 Tumor/Stromal Cells Expression on Progressive Growth of Ovarian Neoplasms

被引：24

作者：

Grelewski, Piotr Grzegorz ^{[1
]}

Bar, Julia Krystyna ^{[1
]}

机构：

[1] Wroclaw Med Univ, Dept Pathomorphol & Oncol Cytol, PL-50556 Wroclaw, Poland

来源：

CANCER INVESTIGATION | 2013年 / 31卷 / 07期

关键词：

Ovarian cancer; Immunology/immunobiology; Invasion & metastasis; Molecular biology; MATRIX METALLOPROTEINASE-2; IN-VIVO; METASTASIS; INVASION; CARCINOMA;

D O I：

10.3109/07357907.2013.820320

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The aim of our study was to evaluate p53 gene/protein status and MMP-2 expression in respect to ovarian tumors progress to define the role of these markers in the metastasis of ovarian carcinomas. MMP-2 and p53 alterations were evaluated on 80 malignant, 30 benign ovarian tumors, and 62 metastatic lesions by using HRM method for mutations in p53 gene and by using RT-PCR for mRNA MMP-2 level. Our data indicate that parallel expression of MMP-2 epithelial/stromal cells and p53 may enhance cells invasion and metastasis in ovarian carcinoma.

引用

页码：472 / 479

页数：8

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