Functional Activity of Varicose Human Great Saphenous Vein at Different Sites

被引:0
作者
Ziganshin, B. A. [1 ]
Slavin, D. A. [2 ]
Ziganshina, A. P. [1 ]
Dzhordzhikiya, R. K. [1 ]
Ziganshin, A. U. [1 ]
机构
[1] Kazan State Med Univ, Kazan, Russia
[2] Kazan State Med Acad, Kazan, Russia
关键词
P2; receptors; varicose vein; great saphenous vein; RESPONSES; RECEPTORS; TARGETS;
D O I
10.1007/s10517-013-2169-2
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
Experiments on isolated preparations of varicose human great saphenous vein revealed different sensitivity of the distal and proximal portions to P2X receptor agonist alpha,beta-methylene-ATP, but not to norepinephrine and histamine. It is suggested that restructuring of the P2 receptor system plays an important role in the pathogenesis of varicose veins, which affects the trunk of the great saphenous vein in varying degrees.
引用
收藏
页码:429 / 432
页数:4
相关论文
共 10 条
  • [1] The regulation of vascular function by P2 receptors: multiple sites and multiple receptors
    Boarder, MR
    Hourani, SMO
    [J]. TRENDS IN PHARMACOLOGICAL SCIENCES, 1998, 19 (03) : 99 - 107
  • [2] Potential therapeutic targets in the rapidly expanding field of purinergic signalling
    Burnstock, G
    [J]. CLINICAL MEDICINE, 2002, 2 (01) : 45 - 53
  • [3] Pharmacological analysis of neurogenic, sympathetic responses mediated through alpha-1-, alpha-2-adrenergic and purinergic receptors in the dog saphenous vein
    Hiraoka, Y
    Taniguchi, T
    Oshita, M
    Muramatsu, I
    [J]. PHARMACOLOGY, 2000, 60 (04) : 188 - 194
  • [4] Alterations in purinoceptor expression in human long saphenous vein during varicose disease
    Metcalfe, M. J.
    Baker, D. M.
    Turmaine, M.
    Burnstock, G.
    [J]. EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY, 2007, 33 (02) : 239 - 250
  • [5] REPORTING STANDARDS IN VENOUS DISEASE - AN UPDATE
    PORTER, JM
    MONETA, GL
    BEEBE, HG
    BERGAN, JJ
    BERGQVIST, D
    EKLOF, B
    ERIKSSON, I
    GOLDMAN, MP
    GREENFIELD, LJ
    HOBSON, RW
    JUHAN, C
    KISTNER, RL
    LABROPOULOS, N
    MALOUF, GM
    MENZOIAN, JO
    MYERS, KA
    NEGLEN, P
    NICOLAIDES, AN
    ODONNELL, TF
    PARTSCH, H
    PERRIN, M
    RAJU, S
    RICH, NM
    RICHARDSON, G
    SCHANZER, H
    SMITH, PC
    STRANDNESS, DE
    SUMNER, DS
    [J]. JOURNAL OF VASCULAR SURGERY, 1995, 21 (04) : 635 - 645
  • [6] Ziganshin A. U., 2011, Vestnik Rossiiskoi Akademii Meditsinskikh Nauk, P32
  • [7] Ziganshin A.U., 2009, P2 RECEPTORS PROMISI
  • [8] Varicose disease affects the P2 receptor-mediated responses of human greater saphenous vein
    Ziganshin, AU
    Khaziakhmetov, DF
    Ziganshina, LE
    Khaziakhmetova, VN
    Jourjikiya, RK
    Ziganshin, BA
    Giniyatova, LR
    Burnstock, G
    [J]. VASCULAR PHARMACOLOGY, 2004, 42 (01) : 17 - 21
  • [9] Effect of PPADS on P2X receptor-mediated responses of human blood vessels
    Ziganshin, AU
    Ziganshin, BA
    Giniyatova, LR
    Dzhordzhikiya, RK
    [J]. BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE, 2004, 137 (03) : 284 - 287
  • [10] Contractile activity of human greater saphenous vein mediated by P2-receptors
    Ziganshin, AU
    Khaziakhmetov, AF
    Ziganshina, LE
    Khaziakhmetova, VN
    Dzhordzhikiya, RK
    Burnstock, G
    [J]. BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE, 2003, 135 (01) : 23 - 25