Inhibition of UVB-Induced Nonmelanoma Skin Cancer: A Path from Tea to Caffeine to Exercise to Decreased Tissue Fat

被引:9
作者
Conney, Allan H. [1 ]
Lou, You-Rong [1 ]
Nghiem, Paul [2 ]
Bernard, Jamie J. [1 ]
Wagner, George C. [3 ]
Lu, Yao-Ping [1 ]
机构
[1] Rutgers State Univ, Dept Biol Chem, Ernest Mario Sch Pharm, Susan Lehman Cullman Lab Canc Res, Piscataway, NJ 08854 USA
[2] Univ Washington, Sch Med, Fred Hutchinson Canc Res Ctr, Div Dermatol,Dept Med, Seattle, WA 98109 USA
[3] Rutgers State Univ, Dept Psychol, Piscataway, NJ 08854 USA
来源
NATURAL PRODUCTS IN CANCER PREVENTION AND THERAPY | 2013年 / 329卷
关键词
Adipokines; Sunlight-induced skin cancer; INDUCED APOPTOSIS; GREEN TEA; DECAFFEINATED TEA; CARCINOGENESIS; MICE; EPIDERMIS; COFFEE; TUMORS; CELLS; P53;
D O I
10.1007/128_2012_336
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Oral administration of green tea, black tea, or caffeine (but not the decaffeinated teas) inhibited ultraviolet B radiation (UVB)-induced skin carcinogenesis in SKH-1 mice. Studies with caffeine indicated that its inhibitory effect on the ATR/Chk1 pathway is an important mechanism for caffeine's inhibition of UVB-induced carcinogenesis. The regular teas or caffeine increased locomotor activity and decreased tissue fat. In these studies, decreased dermal fat thickness was associated with a decrease in the number of tumors per mouse. Administration of caffeine, voluntary exercise, and removal of the parametrial fat pads all stimulated UVB-induced apoptosis, inhibited UVB-induced carcinogenesis, and stimulated apoptosis in UVB-induced tumors. These results suggest that caffeine administration, voluntary exercise, and removal of the parametrial fat pads inhibit UVB-induced carcinogenesis by stimulating UVB-induced apoptosis and by enhancing apoptosis in DNA-damaged precancer cells and in cancer cells. We hypothesize that tissue fat secretes antiapoptotic adipokines that have a tumor promoting effect.
引用
收藏
页码:61 / 72
页数:12
相关论文
共 27 条
[1]   Daily coffee consumption and prevalence of nonmelanoma skin cancer in Caucasian women [J].
Abel, Ernest L. ;
Hendrix, Susan O. ;
McNeeleya, S. Gene ;
Johnson, Karen C. ;
Rosenberg, Carol A. ;
Mossavar-Rahmani, Yasmin ;
Vitolins, Mara ;
Kruger, Michael .
EUROPEAN JOURNAL OF CANCER PREVENTION, 2007, 16 (05) :446-452
[2]  
Athas WF, 2003, CANCER EPIDEM BIOMAR, V12, P1105
[3]   Novel functions of TIMPs in cell signaling [J].
Chirco, R ;
Liu, XW ;
Jung, KK ;
Kim, HRC .
CANCER AND METASTASIS REVIEWS, 2006, 25 (01) :99-113
[4]   Stimulatory effect of oral administration of tea, coffee or caffeine on UVB-induced apoptosis in the epidermis of SKH-1 mice [J].
Conney, Allan H. ;
Zhou, Sherry ;
Lee, Mao-Jung ;
Xie, Jian Guo ;
Yang, Chung S. ;
Lou, You Rong ;
Lu, YaoPing .
TOXICOLOGY AND APPLIED PHARMACOLOGY, 2007, 224 (03) :209-213
[5]   ATR-Chk1 Pathway Inhibition Promotes Apoptosis after UV Treatment in Primary Human Keratinocytes: Potential Basis for the UV Protective Effects of Caffeine [J].
Heffernan, Timothy P. ;
Kawasumi, Masaoki ;
Blasina, Alessandra ;
Anderes, Kenna ;
Conney, Allan H. ;
Nghiem, Paul .
JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2009, 129 (07) :1805-1815
[6]  
Huang MT, 1997, CANCER RES, V57, P2623
[7]  
JACOBSEN BK, 1986, JNCI-J NATL CANCER I, V76, P823
[8]   Protection from UV-induced skin carcinogenesis by genetic inhibition of the ataxia telangiectasia and Rad3-related (ATR) kinase [J].
Kawasumi, Masaoki ;
Lemos, Bianca ;
Bradner, James E. ;
Thibodeau, Renee ;
Kim, Yong-son ;
Schmidt, Miranda ;
Higgins, Erin ;
Koo, Sang-wahn ;
Angle-Zahn, Aimee ;
Chen, Adam ;
Levine, Douglas ;
Lynh Nguyen ;
Heffernan, Timothy P. ;
Longo, Isabel ;
Mandinova, Anna ;
Lu, Yao-Ping ;
Conney, Allan H. ;
Nghiem, Paul .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2011, 108 (33) :13716-13721
[9]   Effects of high-fat diets rich in either omega-3 or omega-6 fatty acids on UVB-induced skin carcinogenesis in SKH-1 mice [J].
Lou, You-Rong ;
Peng, Qing-Yun ;
Li, Tao ;
Medvecky, Christopher M. ;
Lin, Yong ;
Shih, Weichung Joe ;
Conney, Allan H. ;
Shapses, Sue ;
Wagner, George C. ;
Lu, Yao-Ping .
CARCINOGENESIS, 2011, 32 (07) :1078-1084
[10]   Effects of oral administration of tea, decaffeinated tea, and caffeine on the formation and growth of tumors in high-risk SKH-1 mice previously treated with ultraviolet B light [J].
Lou, YR ;
Lu, YP ;
Xie, JG ;
Huang, MT ;
Conney, AH .
NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL, 1999, 33 (02) :146-153