Rh[III]-Catalyzed C-H Amidation Using Aroyloxycarbamates To Give N-Boc Protected Arylamines

被引：153

作者：

Grohmann, Christoph ^{[1
]}

Wang, Honggen ^{[1
]}

Glorius, Frank ^{[1
]}

机构：

[1] Univ Munster, Inst Organ Chem, D-48149 Munster, Germany

来源：

ORGANIC LETTERS | 2013年 / 15卷 / 12期

基金：

欧洲研究理事会;

关键词：

CATALYZED DIRECT AMINATION; BOND FORMATION; BORONIC ACIDS; RHODIUM; FUNCTIONALIZATION; ARENES; ACTIVATION; MECHANISM; ALKYNES; AZOLES;

D O I：

10.1021/ol401209f

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The Rh(III)-catalyzed amidation of C(sp(2))-H bonds by the use of electron-deficient aroyloxycarbamates as efficient electrophilic amidation partners is reported. The reaction proceeded under mild conditions with broad functional group tolerance, and pyridine and O-methyl hydroxamic acids serve as efficient directing groups, giving access to valuable N-Boc protected arylamines (also Fmoc and Cbz). Preliminary mechanistic experiments are discussed.

引用

页码：3014 / 3017

页数：4

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