Study of plant coumarins. 12*. Synthesis of 2-(1,2,3-triazolyl)-modified furocoumarins

被引：11

作者：

Lipeeva, A. V. ^{[1
]}

Shults, E. E. ^{[1
]}

Makhneva, E. A. ^{[1
]}

Shakirov, M. M. ^{[1
]}

Tolstikov, G. A. ^{[1
]}

机构：

[1] Russian Acad Sci, Siberian Branch, NN Vorozhtsov Inst Organ Chem, Novosibirsk 630090, Russia

来源：

CHEMISTRY OF HETEROCYCLIC COMPOUNDS | 2013年 / 49卷 / 04期

基金：

俄罗斯基础研究基金会;

关键词：

alkynes; 2-bromooreoselone; dicoumarins; triazolylfurocoumarins; CLICK; 1,2,3-TRIAZOLES; INHIBITORS; CHEMISTRY; ANALOGS;

D O I：

10.1007/s10593-013-1281-6

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Bromooreoselone reacted with sodium azide to give 2-azidooreoselone, which was highly reactive in a catalytic Huisgen reaction with various terminal alkynes. These reactions yielded 4-substituted 2-(triazol-1-yl)furocoumarins. The reaction of oreoselone azide with dimethyl acetylene-1,2-di-carboxylate gave 2-[(4,5-dimethoxycarbonyl)triazolyl]oreoselone and reaction with 7-ethynyl-6-methoxycarbonylcoumarin gave 1,4-dicoumarin-substituted 1,2,3-triazole.

引用

页码：551 / 560

页数：10

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