Protective effect of resveratrol against oxidative damage to ovarian reserve in female Sprague-Dawley rats

被引:52
作者
Ozcan, Pinar [1 ]
Ficicioglu, Cem [1 ]
Yildirim, Ozge Kizilkale [1 ]
Ozkan, Ferda [2 ]
Akkaya, Hatice [3 ]
Aslan, Ismail [4 ]
机构
[1] Yeditepe Univ, Dept Obstet & Gynecol, Fac Med, Istanbul, Turkey
[2] Yeditepe Univ, Dept Pathol, Fac Med, Istanbul, Turkey
[3] Yeditepe Univ, Expt Res Ctr YUDETAM, Fac Med, Istanbul, Turkey
[4] Yeditepe Univ, Fac Pharm, Dept Pharmaceut Technol, Istanbul, Turkey
关键词
AMH; ovarian reserve; oxidative damage; resveratrol; HORMONE AGONIST; STRESS; ANTIOXIDANTS; STEROIDOGENESIS; CHEMOTHERAPY; MECHANISMS; CELLS;
D O I
10.1016/j.rbmo.2015.06.007
中图分类号
R71 [妇产科学];
学科分类号
100211 ;
摘要
An increased accumulation of intracellular levels of reactive oxygen species with time may play an important role in the process of ageing. The antioxidant properties of resveratrol are dependent upon the up-regulation of endogenous cellular antioxidant systems. We evaluated whether resveratrol has protective antioxidant effects on ovarian damage related to oxidative stress in a rat model. Twenty-four female rats were randomly divided into three groups and were given saline (group 1: control); intraperitoneal cisplatin, 4.5 mg/kg, two weekly doses in total (group 2); or cisplatin, 4.5 mg/kg plus intraperitoneal resveratrol 10 mg/kg/day, 24 h before the administration of cisplatin (group 3). Serum anti-Mullerian hormone (AMH) concentrations were significantly lower in group 2 than in group 3 (P < 0.01 and P = 0.04, respectively). The evaluation of the atretic and antral follicle counts revealed statistically significant differences between the groups (P = 0.04 and P < 0.01, respectively). A statistically significant difference was observed in the follicle count positive for AMH between the groups (P = 0.01). Oxidative stress plays an important role in the process of ovarian ageing. Because of its natural antioxidant properties, resveratrol may be an effective option in protecting ovarian tissue against oxidative damage. (C) 2015 Reproductive Healthcare Ltd. Published by Elsevier Ltd. All rights reserved.
引用
收藏
页码:404 / 410
页数:7
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