Mice lacking neuropeptide Y show increased sensitivity to cocaine

被引：13

作者：

Sorensen, Gunnar ^{[2
,3
]}

Woldbye, David P. D. ^{[1
,2
]}

机构：

[1] Univ Copenhagen, Panum Inst, Dept Neurosci & Pharmacol, Prot Lab, DK-2200 Copenhagen, Denmark

[2] Univ Copenhagen, Psychiat Ctr Copenhagen, Dept Neurosci & Pharmacol, Lab Neuropsychiat, DK-2200 Copenhagen, Denmark

[3] Univ Copenhagen, Mol Neuropharmacol Lab, Dept Neurosci & Pharmacol, DK-2200 Copenhagen, Denmark

来源：

SYNAPSE | 2012年 / 66卷 / 09期

关键词：

neuropeptide Y; cocaine; dopamine transporter; reinforcement; addiction; MORPHINE-WITHDRAWAL; DOPAMINE; RECEPTOR; ETHANOL; BRAIN; ADDICTION; SEIZURES; RATS;

D O I：

10.1002/syn.21568

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

There is increasing data implicating neuropeptide Y (NPY) in the neurobiology of addiction. This study explored the possible role of NPY in cocaine-induced behavior using NPY knockout mice. The transgenic mice showed a hypersensitive response to cocaine in three animal models of cocaine addiction. Whether this is due to an observed compensatory increase in striatal dopamine transporter binding or an anxiogenic phenotype of the transgenic mice remains to be determined. Synapse 66:840843, 2012. (c) 2012 Wiley Periodicals, Inc.

引用

页码：840 / 843

页数：4

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