Membrane activity of antimicrobial phenylene ethynylene based polymers and oligomers

被引:62
作者
Wang, Ying [1 ,2 ]
Chi, Eva Y. [1 ]
Schanze, Kirk S. [3 ]
Whitten, David G. [1 ]
机构
[1] Univ New Mexico, Dept Chem & Nucl Engn, Ctr Biomed Engn, Albuquerque, NM 87131 USA
[2] Univ New Mexico, Dept Chem & Chem Biol, Albuquerque, NM 87131 USA
[3] Univ Florida, Dept Chem, Gainesville, FL 32611 USA
关键词
DE-NOVO DESIGN; CONJUGATED POLYELECTROLYTES; ANTIBACTERIAL ACTIVITY; PERTURBATION ACTIVITY; BIOCIDAL ACTIVITY; MECHANISM; PEPTIDES; LIGHT; AGGREGATION; BACTERIAL;
D O I
10.1039/c2sm25238d
中图分类号
O64 [物理化学(理论化学)、化学物理学];
学科分类号
070304 ; 081704 ;
摘要
Poly(phenylene ethynylene) (PPE)-based cationic conjugated polyelectrolytes (CPEs) and cationic phenylene ethynylene oligomers (OPEs) exhibit broad-spectrum antimicrobial activity and one of their main targets is believed to be the bacterial cell wall and membrane. This review focuses on recent progress made in elucidating the membrane perturbation mechanism of these antimicrobial molecules. We first review the membrane action models proposed for naturally occurring antimicrobial peptides (AMPs) because the membrane activities of CPEs and OPEs and AMPs are believed to be mediated by the same physical and chemical driving forces. An overview of the current research progress on the interactions between CPE and OPE compounds and model membranes is then presented, including main parameters controlling the membrane activity of these synthetic antimicrobial compounds. Combined with direct visualization of CPE and OPE induced changes in bacterial cell morphology, evidence to date points to a carpet or detergent-like pathway by which these compounds perturb the lipid membrane. Lastly, general trends between the membrane activity and dark antimicrobial activity of the CPEs and OPEs are reviewed to shed light on the structure-function relationship of this novel class of biocidal compounds.
引用
收藏
页码:8547 / 8558
页数:12
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