The Overexpression of FEN1 and RAD54B May Act as Independent Prognostic Factors of Lung Adenocarcinoma

被引：19

作者：

Hwang, Jau-Chung ^{[1
,2
]}

Sung, Wen-Wei ^{[3
,4
,5
]}

Tu, Hung-Pin ^{[6
]}

Hsieh, Kun-Chou ^{[7
]}

Yeh, Chung-Min ^{[8
]}

Chen, Chih-Jung ^{[3
,5
,8
]}

Tai, Hui-Chun ^{[8
]}

Hsu, Chao-Tien ^{[9
,10
]}

Shieh, Grace S. ^{[11
]}

Chang, Jan-Gowth ^{[12
,13
]}

Yeh, Kun-Tu ^{[3
,8
]}

Liu, Ta-Chih ^{[1
,14
]}

机构：

[1] Kaohsiung Med Univ, Grad Inst Clin Med, Coll Med, Kaohsiung, Taiwan

[2] Lin Shin Hosp, Dept Pathol, Taichung, Taiwan

[3] Chung Shan Med Univ, Sch Med, Taichung, Taiwan

[4] Chung Shan Med Univ Hosp, Dept Med Educ, Taichung, Taiwan

[5] Jen Teh Jr Coll Med Nurisng & Management, Dept Med Technol, Miaoli, Taiwan

[6] Kaohsiung Med Univ, Sch Med, Dept Publ Hlth & Environm Med, Coll Med, Kaohsiung, Taiwan

[7] E Da Hosp, Div Thorac Surg, Dept Surg, Kaohsiung, Taiwan

[8] Changhua Christian Hosp, Dept Surg Pathol, Changhua, Taiwan

[9] E Da Hosp, Dept Pathol, Kaohsiung, Taiwan

[10] I Shou Univ, Kaohsiung, Taiwan

[11] Acad Sinica, Inst Stat Sci, Taipei 11529, Taiwan

[12] China Med Univ, Dept Lab Med, China Med Univ Hosp, Taichung, Taiwan

[13] China Med Univ, Ctr RNA Biol & Clin Applicat, China Med Univ Hosp, Taichung, Taiwan

[14] Kaohsiung Med Univ Hosp, Div Hematol Oncol, Dept Internal Med, Kaohsiung, Taiwan

来源：

PLOS ONE | 2015年 / 10卷 / 10期

关键词：

COLORECTAL-CANCER CELLS; SYNTHETIC LETHALITY; GENOMIC INSTABILITY; FLAP ENDONUCLEASE-1; TARGETED THERAPIES; REPAIR; INHIBITION; RISK; CHEMOPREVENTION; MUTATIONS;

D O I：

10.1371/journal.pone.0139435

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Synthetic lethality arises when a combination of mutations in two or more genes leads to cell death. However, the prognostic role of concordant overexpression of synthetic lethality genes in protein level rather than a combination of mutations is not clear. In this study, we explore the prognostic role of combined overexpression of paired genes in lung adenocarcinoma. We used immunohistochemical staining to investigate 24 paired genes in 93 lung adenocarcinoma patients and Kaplan-Meier analysis and Cox proportional hazards models to evaluate their prognostic roles. Among 24 paired genes, only FEN1 (Flap endonuclease 1) and RAD54B (RAD54 homolog B) were overexpressed in lung adenocarcinoma patients with poor prognosis. Patients with expression of both FEN1 and RAD54B were prone to have advanced nodal involvement and significantly poor prognosis (HR = 2.35, P = 0.0230). These results suggest that intensive follow up and targeted therapy might improve clinical outcome for patients who show expression of both FEN1 and RAD54B.

引用

页数：12

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