The innate immune response in human tuberculosis

被引：98

作者：

Lerner, Thomas R. ^{[1
]}

Borel, Sophie ^{[1
]}

Gutierrez, Maximiliano G. ^{[1
]}

Borel, Sophie ^{[1
]}

机构：

[1] Francis Crick Inst, Mill Hill Lab, London, England

来源：

CELLULAR MICROBIOLOGY | 2015年 / 17卷 / 09期

基金：

英国医学研究理事会; 英国惠康基金;

关键词：

VIRULENT MYCOBACTERIUM-TUBERCULOSIS; HUMAN DENDRITIC CELLS; ALVEOLAR MACROPHAGES; HUMAN-NEUTROPHILS; VITAMIN-D; PROTEIN; LIPOARABINOMANNAN; PHAGOSOME; INFECTION; AUTOPHAGY;

D O I：

10.1111/cmi.12480

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Mycobacterium tuberculosis (Mtb) infection can be cleared by the innate immune system before the initiation of an adaptive immune response. This innate protection requires a variety of robust cell autonomous responses from many different host immune cell types. However, Mtb has evolved strategies to circumvent some of these defences. In this mini-review, we discuss these host-pathogen interactions with a focus on studies performed in human cells and/or supported by human genetics studies (such as genome-wide association studies).

引用

页码：1277 / 1285

页数：9

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