An ensemble code in medial prefrontal cortex links prior events to outcomes during learning

被引:11
作者
Maggi, Silvia [1 ,2 ]
Peyrache, Adrien [3 ]
Humphries, Mark D. [1 ,2 ]
机构
[1] Univ Nottingham, Sch Psychol, Nottingham NG7 2RD, England
[2] Univ Manchester, Fac Biol Med & Hlth, Manchester M13 9PT, Lancs, England
[3] McGill Univ, Montreal Neurol Inst, Montreal, PQ H3A 2B4, Canada
基金
英国医学研究理事会;
关键词
MIDBRAIN DOPAMINE NEURONS; REWARD PREDICTION ERROR; WORKING-MEMORY; ADAPTIVE-CONTROL; DECISION-MAKING; RAT; TASKS; OSCILLATIONS; MECHANISMS; SEQUENCES;
D O I
10.1038/s41467-018-04638-2
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
The prefrontal cortex is implicated in learning the rules of an environment through trial and error. But it is unclear how such learning is related to the prefrontal cortex's role in short-term memory. Here we ask if the encoding of short-term memory in prefrontal cortex is used by rats learning decision rules in a Y-maze task. We find that a similar pattern of neural ensemble activity is selectively recalled after reinforcement for a correct decision. This reinforcement-selective recall only reliably occurs immediately before the abrupt behavioural transitions indicating successful learning of the current rule, and fades quickly thereafter. We could simultaneously decode multiple, retrospective task events from the ensemble activity, suggesting the recalled ensemble activity has multiplexed encoding of prior events. Our results suggest that successful trial-and-error learning is dependent on reinforcement tagging the relevant features of the environment to maintain in prefrontal cortex short-term memory.
引用
收藏
页数:12
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