Sequence Analysis and Polymorphism Discovery in 4 Members of the Bovine Cathelicidin Gene Family

被引：11

作者：

Gillenwaters, Erin N. ^{[1
]}

Seabury, Christopher M. ^{[1
]}

Elliott, Janice S. ^{[1
]}

Womack, James E. ^{[1
]}

机构：

[1] Texas A&M Univ, Coll Vet Med, Dept Vet Pathobiol, College Stn, TX 77843 USA

来源：

JOURNAL OF HEREDITY | 2009年 / 100卷 / 02期

关键词：

antimicrobial peptide; cathelicidin; cattle; innate immunity; PROTEIN DOMAIN ARCHITECTURES; ANTIMICROBIAL PEPTIDE; VARIABILITY; RESPONSES;

D O I：

10.1093/jhered/esn112

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Cathelicidins (CATHLs) are small, cationic antimicrobial peptides that establish an early innate immune defense against infections in mammals. Beyond their wide spectrum of antimicrobial activity, these peptides play important roles in wound repair, chemotactic activity, and apoptosis. Thus, polymorphisms present in bovine CATHLs 2, 5, 6, and 7 could potentially underlie inherited differences in innate immunity and disease resistance. The purpose of the present study was to characterize single nucleotide polymorphisms (SNPs) and insertion-deletion (indel) polymorphisms within the bovine CATHL gene family. Comparative sequence analysis for 10 domestic cattle breeds representing both Bos taurus and Bos indicus revealed 60 SNPs, 7 of which were nonsynonymous and 5 indel mutations. Characterization of these novel polymorphisms is central to developing a firm understanding regarding what effects, if any, nonsynonymous CATHL variation has with respect to bovine innate immunity.

引用

页码：241 / 245

页数：5

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