Eosinophilic asthma: Insights into the effects of reducing IL-5 receptor-positive cell levels

被引:8
作者
Assa'ad, Amal H. [1 ]
Rothenberg, Marc E. [1 ]
机构
[1] Cincinnati Childrens Hosp Med Ctr, Div Allergy & Immunol, Cincinnati, OH 45229 USA
关键词
Eosinophils; IL-5; anti-IL-5; receptor; benralizumab; steroid-dependent asthma; PLACEBO-CONTROLLED TRIAL; DOUBLE-BLIND; MEPOLIZUMAB; ESOPHAGITIS; RESLIZUMAB; ANTIBODY; CHILDREN;
D O I
10.1016/j.jaci.2013.08.036
中图分类号
R392 [医学免疫学];
学科分类号
100102 ;
摘要
引用
收藏
页码:1097 / 1098
页数:2
相关论文
共 9 条
[1]   An Antibody Against IL-5 Reduces Numbers of Esophageal Intraepithelial Eosinophils in Children With Eosinophilic Esophagitis [J].
Assa'ad, Amal H. ;
Gupta, Sandeep K. ;
Collins, Margaret H. ;
Thomson, Mike ;
Heath, Amy T. ;
Smith, Deborah A. ;
Perschy, Teresa L. ;
Jurgensen, Cynthia H. ;
Ortega, Hector G. ;
Aceves, Seema S. .
GASTROENTEROLOGY, 2011, 141 (05) :1593-1604
[2]   Safety profile, pharmacokinetics, and biologic activity of MEDI-563, an anti-IL-5 receptor α antibody, in a phase I study of subjects with mild asthma [J].
Busse, William W. ;
Katial, Rohit ;
Gossage, David ;
Sari, Suha ;
Wang, Bing ;
Kolbeck, Roland ;
Coyle, Anthony J. ;
Koike, Masamichi ;
Spitalny, George L. ;
Kiener, Peter A. ;
Geba, Gregory P. ;
Molfino, Nestor A. .
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2010, 125 (06) :1237-1244
[3]   Reslizumab for Poorly Controlled, Eosinophilic Asthma A Randomized, Placebo-controlled Study [J].
Castro, Mario ;
Mathur, Sameer ;
Hargreave, Frederick ;
Boulet, Louis-Philippe ;
Xie, Fang ;
Young, James ;
Wilkins, H. Jeffrey ;
Henkel, Timothy ;
Nair, Parameswaran .
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2011, 184 (10) :1125-1132
[4]   Mepolizumab and Exacerbations of Refractory Eosinophilic Asthma [J].
Haldar, Pranabashis ;
Brightling, Christopher E. ;
Hargadon, Beverley ;
Gupta, Sumit ;
Monteiro, William ;
Sousa, Ana ;
Marshall, Richard P. ;
Bradding, Peter ;
Green, Ruth H. ;
Wardlaw, Andrew J. ;
Pavord, Ian D. .
NEW ENGLAND JOURNAL OF MEDICINE, 2009, 360 (10) :973-984
[5]   Effects of benralizumab on airway eosinophils in asthmatic patients with sputum eosinophilia [J].
Laviolette, Michel ;
Gossage, David L. ;
Gauvreau, Gail ;
Leigh, Richard ;
Olivenstein, Ron ;
Katial, Rohit ;
Busse, William W. ;
Wenzel, Sally ;
Wu, Yanping ;
Datta, Vivekananda ;
Kolbeck, Roland ;
Molfino, Nestor A. .
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2013, 132 (05) :1086-+
[6]  
Molfino NA, 2012, AM J RESP CRIT CARE, V185, pA2753
[7]   Mepolizumab for Prednisone-Dependent Asthma with Sputum Eosinophilia [J].
Nair, Parameswaran ;
Pizzichini, Marcia M. M. ;
Kjarsgaard, Melanie ;
Inman, Mark D. ;
Efthimiadis, Ann ;
Pizzichini, Emilio ;
Hargreave, Frederick E. ;
O'Byrne, Paul M. .
NEW ENGLAND JOURNAL OF MEDICINE, 2009, 360 (10) :985-993
[8]   Mepolizumab for severe eosinophilic asthma (DREAM): a multicentre, double-blind, placebo-controlled trial [J].
Pavord, Ian D. ;
Korn, Stephanie ;
Howarth, Peter ;
Bleecker, Eugene R. ;
Buhl, Roland ;
Keene, Oliver N. ;
Ortega, Hector ;
Chanez, Pascal .
LANCET, 2012, 380 (9842) :651-659
[9]   Reslizumab in children and adolescents with eosinophilic esophagitis: Results of a double-blind, randomized, placebo-controlled trial [J].
Spergel, Jonathan M. ;
Rothenberg, Marc E. ;
Collins, Margaret H. ;
Furuta, Glenn T. ;
Markowitz, Jonathan E. ;
Fuchs, George, III ;
O'Gorman, Molly A. ;
Abonia, Juan Pablo ;
Young, James ;
Henkel, Timothy ;
Wilkins, H. Jeffrey ;
Liacouras, Chris A. .
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2012, 129 (02) :456-U275