Hypoxia-inducible factor signaling in pulmonary hypertension

被引：148

作者：

Pullamsetti, Soni Savai ^{[1
,2
,3
,4
]}

Mamazhakypov, Argen ^{[1
,2
]}

Weissmann, Norbert ^{[3
,4
]}

Seeger, Werner ^{[1
,2
,3
,4
,5
]}

Savai, Rajkumar ^{[1
,2
,3
,4
,5
,6
]}

机构：

[1] German Ctr Lung Res DZL, Dept Lung Dev & Remodeling, Max Planck Inst Heart & Lung Res, Bad Nauheim, Germany

[2] Cardiopulm Inst CPI, Bad Nauheim, Germany

[3] Justus Liebig Univ, Dept Internal Med, Univ Giessen & Marburg Lung Ctr, DZL, Giessen, Germany

[4] Justus Liebig Univ, CPI, Giessen, Germany

[5] Justus Liebig Univ, Inst Lung Hlth ILH, Giessen, Germany

[6] Goethe Univ, Frankfurt Canc Inst FCI, Frankfurt, Germany

来源：

JOURNAL OF CLINICAL INVESTIGATION | 2020年 / 130卷 / 11期

基金：

欧洲研究理事会;

关键词：

SMOOTH-MUSCLE-CELLS; PLACENTA GROWTH-FACTOR; ARTERIAL-HYPERTENSION; ENDOTHELIAL-CELLS; UP-REGULATION; INDUCED PROLIFERATION; MICE LACKING; PHYSIOLOGICAL-RESPONSES; RECIPROCAL REGULATION; INTERMITTENT HYPOXIA;

D O I：

10.1172/JCI137558

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Pulmonary hypertension (PH) is characterized by pulmonary artery remodeling that can subsequently culminate in right heart failure and premature death. Emerging evidence suggests that hypoxia-inducible factor (HIF) signaling plays a fundamental and pivotal role in the pathogenesis of PH. This Review summarizes the regulation of HIF isoforms and their impact in various PH subtypes, as well as the elaborate conditional and cell-specific knockout mouse studies that brought the role of this pathway to light. We also discuss the current preclinical status of pan- and isoform-selective HIF inhibitors, and propose new research areas that may facilitate HIF isoform-specific inhibition as a novel therapeutic strategy for PH and right heart failure.

引用

收藏

页码：5638 / 5651

页数：14

相关论文

共 151 条

[41] Autosomal dominant erythrocytosis and pulmonary arterial hypertension associated with an activating HIF2α mutation [J].

Gale, Daniel P. ;

Harten, Sarah K. ;

Reid, Cecil D. L. ;

Tuddenham, Edward G. D. ;

Maxwell, Patrick H. .

BLOOD, 2008, 112 (03) :919-921

[42] Altered Hypoxic-Adenosine Axis and Metabolism in Group III Pulmonary Hypertension [J].

Garcia-Morales, Luis J. ;

Chen, Ning-Yuan ;

Weng, Tingting ;

Luo, Fayong ;

Davies, Jonathan ;

Philip, Kemly ;

Volcik, Kelly A. ;

Melicoff, Ernestina ;

Amione-Guerra, Javier ;

Bunge, Raquel R. ;

Bruckner, Brian A. ;

Loebe, Matthias ;

Eltzschig, Holger K. ;

Pandit, Lavannya M. ;

Blackburn, Michael R. ;

Karmouty-Quintana, Harry .

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, 2016, 54 (04) :574-583

[43] Hypoxia-induced microRNA-424 expression in human endothelial cells regulates HIF-α isoforms and promotes angiogenesis [J].

Ghosh, Goutam ;

Subramanian, Indira V. ;

Adhikari, Neeta ;

Zhang, Xiaoxiao ;

Joshi, Hemant P. ;

Basi, David ;

Chandrashekhar, Y. S. ;

Hall, Jennifer L. ;

Roy, Sabita ;

Zeng, Yan ;

Ramakrishnan, Sundaram .

JOURNAL OF CLINICAL INVESTIGATION, 2010, 120 (11) :4141-4154

[44] Deletion of Iron Regulatory Protein 1 Causes Polycythemia and Pulmonary Hypertension in Mice through Translational Derepression of HIF2α [J].

Ghosh, Manik C. ;

Zhang, De-Liang ;

Jeong, Suh Young ;

Kovtunovych, Gennadiy ;

Ollivierre-Wilson, Hayden ;

Noguchi, Audrey ;

Tu, Tiffany ;

Senecal, Thomas ;

Robinson, Gabrielle ;

Crooks, Daniel R. ;

Tong, Wing-Hang ;

Ramaswamy, Kavitha ;

Singh, Anamika ;

Graham, Brian B. ;

Tuder, Rubin M. ;

Yu, Zu-Xi ;

Eckhaus, Michael ;

Lee, Jaekwon ;

Springer, Danielle A. ;

Rouault, Tracey A. .

CELL METABOLISM, 2013, 17 (02) :271-281

[45] Erythropoietin-mediated expression of placenta growth factor is regulated via activation of hypoxia-inducible factor-1α and post-transcriptionally by miR-214 in sickle cell disease [J].

Gonsalves, Caryn S. ;

Li, Chen ;

Mpollo, Marthe-Sandrine Eiymo Mwa ;

Pullarkat, Vinod ;

Malik, Punam ;

Tahara, Stanley M. ;

Kalra, Vijay K. .

BIOCHEMICAL JOURNAL, 2015, 468 :409-423

[46] miR-210 has an antiapoptotic effect in pulmonary artery smooth muscle cells during hypoxia [J].

Gou, Deming ;

Ramchandran, Ramaswamy ;

Peng, Xiao ;

Yao, Lijun ;

Kang, Kang ;

Sarkar, Joy ;

Wang, Zhixin ;

Zhou, Goufei ;

Raj, J. Usha .

AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY, 2012, 303 (08) :L682-L691

[47] Upregulation of NAD(P)H oxidase 1 in hypoxia activates hypoxiainducible factor 1 via increase in reactive oxygen species [J].

Goyal, P ;

Weissmann, N ;

Grimminger, F ;

Hegel, C ;

Bader, L ;

Rose, F ;

Fink, L ;

Ghofrani, HA ;

Schermuly, RT ;

Schmidt, HHHW ;

Seeger, W ;

Hänze, J .

FREE RADICAL BIOLOGY AND MEDICINE, 2004, 36 (10) :1279-1288

[48]

Han CF, 2017, EUR REV MED PHARMACO, V21, P4167

[49] Hypoxia induces the dysfunction of human endothelial colony-forming cells via HIF-1α signaling [J].

He, Mengyu ;

Ma, Shuying ;

Cai, Qing ;

Wu, Yan ;

Shao, Chengjie ;

Kong, Hui ;

Wang, Hong ;

Zeng, Xiaoning ;

Xie, Weiping .

RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY, 2018, 247 :87-95

[50] Apigenin attenuates pulmonary hypertension by inducing mitochondria-dependent apoptosis of PASMCs via inhibiting the hypoxia inducible factor 1α-KV1.5 channel pathway [J].

He, Yuanzhou ;

Fang, Xiaoyu ;

Shi, Jing ;

Li, Xiaochen ;

Xie, Min ;

Liu, Xiansheng .

CHEMICO-BIOLOGICAL INTERACTIONS, 2020, 317

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