Hypoxia-inducible factor signaling in pulmonary hypertension

被引：148

作者：

Pullamsetti, Soni Savai ^{[1
,2
,3
,4
]}

Mamazhakypov, Argen ^{[1
,2
]}

Weissmann, Norbert ^{[3
,4
]}

Seeger, Werner ^{[1
,2
,3
,4
,5
]}

Savai, Rajkumar ^{[1
,2
,3
,4
,5
,6
]}

机构：

[1] German Ctr Lung Res DZL, Dept Lung Dev & Remodeling, Max Planck Inst Heart & Lung Res, Bad Nauheim, Germany

[2] Cardiopulm Inst CPI, Bad Nauheim, Germany

[3] Justus Liebig Univ, Dept Internal Med, Univ Giessen & Marburg Lung Ctr, DZL, Giessen, Germany

[4] Justus Liebig Univ, CPI, Giessen, Germany

[5] Justus Liebig Univ, Inst Lung Hlth ILH, Giessen, Germany

[6] Goethe Univ, Frankfurt Canc Inst FCI, Frankfurt, Germany

来源：

JOURNAL OF CLINICAL INVESTIGATION | 2020年 / 130卷 / 11期

基金：

欧洲研究理事会;

关键词：

SMOOTH-MUSCLE-CELLS; PLACENTA GROWTH-FACTOR; ARTERIAL-HYPERTENSION; ENDOTHELIAL-CELLS; UP-REGULATION; INDUCED PROLIFERATION; MICE LACKING; PHYSIOLOGICAL-RESPONSES; RECIPROCAL REGULATION; INTERMITTENT HYPOXIA;

D O I：

10.1172/JCI137558

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Pulmonary hypertension (PH) is characterized by pulmonary artery remodeling that can subsequently culminate in right heart failure and premature death. Emerging evidence suggests that hypoxia-inducible factor (HIF) signaling plays a fundamental and pivotal role in the pathogenesis of PH. This Review summarizes the regulation of HIF isoforms and their impact in various PH subtypes, as well as the elaborate conditional and cell-specific knockout mouse studies that brought the role of this pathway to light. We also discuss the current preclinical status of pan- and isoform-selective HIF inhibitors, and propose new research areas that may facilitate HIF isoform-specific inhibition as a novel therapeutic strategy for PH and right heart failure.

引用

页码：5638 / 5651

页数：14

共 151 条

[1] Digoxin inhibits development of hypoxic pulmonary hypertension in mice [J].

Abud, Edsel M. ;

Maylor, Julie ;

Undem, Clark ;

Punjabi, Arjun ;

Zaiman, Ari L. ;

Myers, Allen C. ;

Sylvester, J. T. ;

Semenza, Gregg L. ;

Shimoda, Larissa A. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2012, 109 (04) :1239-1244

[2] Urocortin-2 improves right ventricular function and attenuates pulmonary arterial hypertension [J].

Adao, Rui ;

Mendes-Ferreira, Pedro ;

Santos-Ribeiro, Diana ;

Maia-Rocha, Carolina ;

Pimentel, Luis D. ;

Monteiro-Pinto, Claudia ;

Mulvaney, Eamon P. ;

Reid, Helen M. ;

Kinsella, B. Therese ;

Potus, Francois ;

Breuils-Bonnet, Sandra ;

Rademaker, Miriam T. ;

Provencher, Steeve ;

Bonnet, Sebastien ;

Leite-Moreira, Adelino F. ;

Bras-Silva, Carmen .

CARDIOVASCULAR RESEARCH, 2018, 114 (08) :1165-1177

[3] Hypoxia-inducible factor-1α regulates KCNMB1 expression in human pulmonary artery smooth muscle cells [J].

Ahn, Yong-Tae ;

Kim, Yu-Mee ;

Adams, Eloa ;

Lyu, Shu-Chen ;

Alvira, Cristina M. ;

Cornfield, David N. .

AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY, 2012, 302 (03) :L352-L359

[4] Endemic polycythemia in Russia: Mutation in the VHL gene [J].

Ang, SO ;

Chen, H ;

Gordeuk, VR ;

Sergueeva, AI ;

Polyakova, LA ;

Miasnikova, GY ;

Kralovics, R ;

Stockton, DW ;

Prchal, JT .

BLOOD CELLS MOLECULES AND DISEASES, 2002, 28 (01) :57-62

[5] Differential function of the prolyl hydroxylases PHD1, PHD2, and PHD3 in the regulation of hypoxia-inducible factor [J].

Appelhoff, RJ ;

Tian, YM ;

Raval, RR ;

Turley, H ;

Harris, AL ;

Pugh, CW ;

Ratcliffe, PJ ;

Gleadle, JM .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2004, 279 (37) :38458-38465

[6] Dysregulated expression of hypoxia-inducible factors augments myofibroblasts differentiation in idiopathic pulmonary fibrosis [J].

Aquino-Galvez, Arnoldo ;

Gonzalez-Avila, Georgina ;

Lorena Jimenez-Sanchez, Laura ;

Aquiles Maldonado-Martinez, Hector ;

Cisneros, Jose ;

Toscano-Marquez, Fernanda ;

Castillejos-Lopez, Manuel ;

Maria Torres-Espindola, Luz ;

Velazquez-Cruz, Rafael ;

Olivera Rodriguez, Victor Hugo ;

Flores-Soto, Edgar ;

Solis-Chagoyan, Hector ;

Cabello, Carlos ;

Zuniga, Joaquin ;

Romero, Yair .

RESPIRATORY RESEARCH, 2019, 20 (1) :130

[7] Regulation of Hypoxia-induced Pulmonary Hypertension by Vascular Smooth Muscle Hypoxia-Inducible Factor-1α [J].

Ball, Molly K. ;

Waypa, Gregory B. ;

Mungai, Paul T. ;

Nielsen, Jacqueline M. ;

Czech, Lyubov ;

Dudley, V. Joseph ;

Beussink, Lauren ;

Dettman, Robert W. ;

Berkelhamer, Sara K. ;

Steinhorn, Robin H. ;

Shah, Sanjiv J. ;

Schumacker, Paul T. .

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2014, 189 (03) :314-324

[8] Loss of smooth muscle cell hypoxia inducible factor-1α underlies increased vascular contractility in pulmonary hypertension [J].

Barnes, Elizabeth A. ;

Chen, Chih-Hsin ;

Sedan, Oshra ;

Cornfield, David N. .

FASEB JOURNAL, 2017, 31 (02) :650-662

[9] Primary endothelial cell-specific regulation of hypoxia-inducible factor (HIF)-1 and HIF-2 and their target gene expression profiles during hypoxia [J].

Bartoszewski, Rafal ;

Moszynska, Adrianna ;

Serocki, Marcin ;

Cabaj, Aleksandra ;

Polten, Andreas ;

Ochocka, Renata ;

Dell'Italia, Louis ;

Bartoszewska, Sylwia ;

Kroliczewski, Jaroslaw ;

Dabrowski, Michal D. ;

Collawn, James F. .

FASEB JOURNAL, 2019, 33 (07) :7929-7941

[10] Redox-sensitive regulation of the HIF pathway under non-hypoxic conditions in pulmonary artery smooth muscle cells [J].

BelAiba, RS ;

Djordjevic, T ;

Bonello, S ;

Flügel, D ;

Hess, J ;

Kietzmann, T ;

Görlach, A .

BIOLOGICAL CHEMISTRY, 2004, 385 (3-4) :249-257

← 1 2 3 4 5 6 7 8 9 10 →