Silver-Catalyzed Tandem Trifluoromethylation and Cyclization of Aryl Isonitriles with the Langlois Reagent

被引：30
作者：
Liu, Yu-Rong [1 ]
Tu, Hai-Yong [1 ]
Zhang, Xing-Guo [1 ]
机构：
[1] Wenzhou Univ, Coll Chem & Mat Engn, Wenzhou 325027, Peoples R China
来源：
SYNTHESIS-STUTTGART | 2015年 / 47卷 / 22期
基金：
中国国家自然科学基金;
关键词：
phenanthridines; trifluoromethylation; Langlois reagent-cyclization; C BOND FORMATION; SOMOPHILIC ISOCYANIDE INSERTION; PHENANTHRIDINE DERIVATIVES; RADICAL TRIFLUOROMETHYLATION; MEDICINAL CHEMISTRY; FLUORINE; 6-(TRIFLUOROMETHYL)PHENANTHRIDINES; 6-TRIFLUOROMETHYL-PHENANTHRIDINES; 2-ISOCYANOBIPHENYLS; INHIBITORS;
D O I：
10.1055/s-0034-1378810
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A mild and efficient procedure for the silver-catalyzed tandem trifluoromethylation and cyclization of aryl isonitriles with the Langlois reagent (sodium triflinate) is developed. A series of trifluoro-methylated phenanthridines is prepared in moderate to good yields from a cheap and stable trifluoromethyl source.
引用
收藏
页码：3460 / 3466
页数：7
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