Chiroptical sensing of unprotected amino acids, hydroxy acids, amino alcohols, amines and carboxylic acids with metal salts

被引：21

作者：

Lynch, Ciaran C. ^{[1
]}

De los Santos, Zeus A. ^{[1
]}

Wolf, Christian ^{[1
]}

机构：

[1] Georgetown Univ, Dept Chem, Washington, DC 20057 USA

来源：

CHEMICAL COMMUNICATIONS | 2019年 / 55卷 / 44期

基金：

美国国家科学基金会;

关键词：

ENANTIOMERIC EXCESS DETERMINATION; CIRCULAR-DICHROISM; NMR ANALYSIS; ABSOLUTE-CONFIGURATION; RAPID-DETERMINATION; CHIRAL COMPOUNDS; SIMPLE PROTOCOLS; COPPER(II); ENANTIOPURITY; COMPLEXES;

D O I：

10.1039/c9cc02525a

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Optical chirality sensing of unprotected amino acids, hydroxy acids, amino alcohols, amines and carboxylic acids based on a practical mix-and-measure protocol with readily available copper, iron, palladium, manganese, cerium or rhodium salts is demonstrated. The generation of strong cotton effects allows quantitative ee analysis of small sample amounts with high speed. In contrast to previously reported assays the use of chromophoric reporter ligands and the control of metal coordination kinetics and redox chemistry are not necessary which greatly simplifies the sensing procedure with the benefit of reduced waste production and cost.

引用

页码：6297 / 6300

页数：4

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