REGULATION OF TH1/TH2 CELLS IN ASTHMA DEVELOPMENT: A MATHEMATICAL MODEL

被引：35

作者：

Kim, Yangjin ^{[1
]}

Lee, Seongwon ^{[2
]}

Kim, You-Sun ^{[3
]}

Lawler, Sean ^{[4
]}

Gho, Yong Song ^{[3
]}

Kim, Yoon-Keun ^{[3
]}

Hwang, Hyung Ju ^{[2
]}

机构：

[1] Konkuk Univ, Dept Math, Seoul, South Korea

[2] Pohang Univ Sci & Technol, Dept Math, Pohang, Gyeongbuk, South Korea

[3] Pohang Univ Sci & Technol, Dept Life Sci, Pohang, Gyeongbuk, South Korea

[4] Univ Leeds, Leeds Inst Mol Med, Leeds, W Yorkshire, England

来源：

MATHEMATICAL BIOSCIENCES AND ENGINEERING | 2013年 / 10卷 / 04期

基金：

新加坡国家研究基金会; 美国国家科学基金会;

关键词：

Asthma; Th1/Th2; cells; microenvironment; LPS; inflammation; CD4(+) T-CELLS; INTERFERON-GAMMA; TNF-ALPHA; IFN-GAMMA; ALLERGEN SENSITIZATION; ENDOTOXIN EXPOSURE; MOTILE RESPONSE; SINGLE-CELL; WHOLE-BLOOD; TH1; CELLS;

D O I：

10.3934/mbe.2013.10.1095

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Airway exposure levels of lipopolysaccharide (LPS) determine type I versus type II helper T cell induced experimental asthma. While high LPS levels induce Th1-dominant responses, low LPS levels derive Th2 cell induced asthma. The present paper develops a mathematical model of asthma development which focuses on the relative balance of Th1 and Th2 cell induced asthma. In the present work we represent the complex network of interactions between cells and molecules by a mathematical model. The model describes the behaviors of cells (Th0, Th1, Th2 and macrophages) and regulatory molecules (IFN-gamma, IL-4, IL-12, TNF-alpha) in response to high, intermediate, and low levels of LPS. The simulations show how variations in the levels of injected LPS affect the development of Th1 or Th2 cell responses through differential cytokine induction. The model also predicts the coexistence of these two types of response under certain biochemical and biomechanical conditions in the microenvironment.

引用

页码：1095 / 1133

页数：39

共 113 条

[61] Late Developmental Plasticity in the T Helper 17 Lineage [J].