Comparison of the human genomic structure of the Runt domain-encoding PEBP2/CBF alpha gene family

被引：19

作者：

Ahn, MY ^{[1
]}

Bae, SC ^{[1
]}

Maruyama, M ^{[1
]}

Ito, Y ^{[1
]}

机构：

[1] KYOTO UNIV,INST VIRUS RES,DEPT VIRAL ONCOL,SAKYO KU,KYOTO 606,JAPAN

来源：

GENE | 1996年 / 168卷 / 02期

关键词：

transcription factor; mouse; acute myeloid leukemia;

D O I：

10.1016/0378-1119(95)00751-2

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

We cloned the human cDNA corresponding to the cDNA (PEBP2 alpha B-451) encoding the mouse polyoma virus enhancer-binding protein 2 alpha B-451, representing a major splice variant from acute myeloid leukemia gene 1 (AML1). Genomic DNA clones of AML1 were also isolated and the exon/intron structure was determined. Furthermore, we determined and compared the genomic structures of three mammalian Runt domain-containing genes, PEBP2 alpha A, AML1/PEBP2 alpha B and PEBP2 alpha C.

引用

页码：279 / 280

页数：2

共 5 条

[1] CLONING, MAPPING AND EXPRESSION OF PEBP2-ALPHA-C, A 3RD GENE ENCODING THE MAMMALIAN RUNT DOMAIN [J].

BAE, SC ;

TAKAHASHI, E ;

ZHANG, YW ;

OGAWA, E ;

SHIGESADA, K ;

NAMBA, Y ;

SATAKE, M ;

ITO, Y .

GENE, 1995, 159 (02) :245-248

[2] PEBP2-ALPHA-B/MOUSE AML1 CONSISTS OF MULTIPLE ISOFORMS THAT POSSESS DIFFERENTIAL TRANSACTIVATION POTENTIALS [J].

BAE, SC ;

OGAWA, E ;

MARUYAMA, M ;

OKA, H ;

SATAKE, M ;

SHIGESADA, K ;

JENKINS, NA ;

GILBERT, DJ ;

COPELAND, NG ;

ITO, Y .

MOLECULAR AND CELLULAR BIOLOGY, 1994, 14 (05) :3242-3252

[3] THE RUNT DOMAIN IDENTIFIES A NEW FAMILY OF HETEROMERIC TRANSCRIPTIONAL REGULATORS [J].

KAGOSHIMA, H ;

SHIGESADA, K ;

SATAKE, M ;

ITO, Y ;

MIYOSHI, H ;

OHKI, M ;

PEPLING, M ;

GERGEN, P .

TRENDS IN GENETICS, 1993, 9 (10) :338-341

[4]

MEYERS S, 1995, MOL CELL BIOL, V15, P1974

[5] T(8-21) BREAKPOINTS ON CHROMOSOME-21 IN ACUTE MYELOID-LEUKEMIA ARE CLUSTERED WITHIN A LIMITED REGION OF A SINGLE GENE, AML1 [J].

MIYOSHI, H ;

SHIMIZU, K ;

KOZU, T ;

MASEKI, N ;

KANEKO, Y ;

OHKI, M .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1991, 88 (23) :10431-10434

← 1 →